Overview of Serum Albumin
Serumski albumin se obično naziva krvnim albuminom. To je albumin (vrsta globularnog proteina) koji se nalazi u krvi kralješnjaka. Albumini su obično prisutni u krvnoj plazmi, a razlikuju se od ostalih krvnih proteina u tome što nisu glikozilirani. Ljudski serumski albumin kodiran je ALB genom, dok drugi oblici sisavaca, poput goveđeg serumskog albumina, imaju slična kemijska svojstva.
Ako nema albumina kao ključne tvari za održavanje onkotskog tlaka potrebnog za pravilnu raspodjelu tjelesnih tekućina između krvnih žila i tjelesnih tkiva, visoki tlak u krvnim žilama tjerao bi više tekućine van u tkiva. Nespecifičnim vezanjem na nekoliko hidrofobnih steroidnih hormona, može služiti kao prijenosnik u plazmi i također se koristi kao transportni protein za hemin i masne kiseline. Prekomjerna ili nedovoljna količina cirkulirajućeg serumskog albumina može biti štetna.
Serumski albumin je široko rasprostranjen u sisavaca.
Human serum albumin (HSA) is a type of serum albumin found in human blood. As the protein with the highest content in human plasma, it accounts for about half of serum protein. It is also a highly water-soluble globular monomeric plasma protein. Its relative molecular weight of 67 KDa, and its composition consists of 585 amino acid residues, one sulfhydryl group and 17 disulfide bridges.
Bovine serum albumin (BSA or "Fraction V") is a type of serum albumin derived from cows that is often used as a protein concentration standard in laboratory experiments. The precursor polypeptide of BSA has a total length of 607 amino acids and18-residue signal peptide at the N-terminus. Another 6 amino acids are cleaved to produce mature BSA protein containing 583 amino acids.
Feline serum albumin (FSA) is a type of albumin derived from cats. It contains single polypeptide with 584 amino acids. According to reports, FSA has high sequence homology with canine serum albumin (CSA), while its dynamic changes are similar to those of HSA and BSA.
Canine serum albumin (CSA) is a type of albumin derived from dog. It contains single polypeptide with 584 amino acids. It is suitable for treating hypovolemic shock or hypoalbuminemia, regardless of its etiology. Canine albumin treatment applies to dogs.
Rekombinantni serumski albumin
Although serum albumin is purified from the blood of humans, cows, and other animals, the use of products derived from animals still has disadvantages such as immunogenicity, difficulty in obtaining sufficient supply, and contamination risks. The advancement of recombinant DNA technology has made it possible for microorganisms to produce various types of serum albumin, such as HAS, BSA, FSA, and CSA. Illustrative examples of the microbial host include bacterial (Escherichia coli, Bacillus subtilis), and yeast (Pichia pastoris, Saccharomyces cerevisiae).
Yaohai Bio-Pharma nudi CDMO rješenje na jednom mjestu za rekombinantni albumin
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