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mRNA Vaccines Against Virus Pathogens

mRNA Vaccines Against Virus Pathogens Česká republika

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mRNA Vaccines Against Virus Pathogens

mRNA vaccines against infectious viruses have shown promising results, and several products have been approved or have undergone human clinical trials.

The general steps in the development of such vaccines provide for 1) structuring of core antigens and optimization of the mRNA sequence; 2) selection of the appropriate combination of mRNA structure, adjuvants, delivery systems, and route of administration; 3) determination of the potency of the mRNA; and 4) study and demonstration of the mechanisms of immune induction.

Here we make a list of some promising mRNA vaccines against virus infections, including SARS-CoV-2 virus, Respiratory Syncytial Virus (RSV), Varicella Zoster Virus (VZV)/ Shingles, Influenza Virus, Cytomegalovirus (CMV), Venezuelan Equine Encephalitis Virus (VEEV), Rabies Virus (RABV), Zika virus (ZIKV), Human Immunodeficiency Virus (HIV), etc.

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  • Custom mRNA Synthesis
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Custom Deliverables

Grade

Deliverables

Specification

Applications

non-GMP

Drug Substance, mRNA

0.1~10 mg (mRNA)

Preclinical research such as cell transfection, Analytical method development, Pre-stability studies, Formulation development

Drug Product, LNP-mRNA

GMP, Sterility

Drug Substance, mRNA

10 mg~70 g

Investigational new drug (IND), Clinical trial authorisation (CTA), Clinical trial supply, Biologic license application (BLA), Commercial supply

Drug Product, LNP-mRNA

5000 vials or pre-filled syringes/ cartridges

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