Stromal cell-derived factor 1 (SDF-1), also known as C-X-C motif chemokine 12 (CXCL12), is a chemokine protein that can activate STAT3 and Akt signaling ways and protect the heart from ischemia-reperfusion injury. As a secreted 89-amino acid protein, SDF-1/CXCL12 binds to chemokine receptor type 4 (CXCR4), a seven-pass G-protein-coupled membrane receptor.
SDF-1 is generated in two forms: SDF-1α/CXCL12a and SDF-1β/CXCL12b. Chemokines are labelled by the presence of four conserved cysteines forming two disulfide bonds. The former one, SDF-1/CXCL12 protein, belong to the CXC class of chemokines, whose original pair of cysteines are separated by one intervening amino acid. Furthermore, the first eight residues at the N-terminal end of SDF-1/CXCL12 provide receptor binding sites, but only Lys-1 and Pro-2 are directly involved in receptor activation.
Potential Applications of SDF-1
SDF-1/CXCL12 recruits cardiac and bone marrow-derived stem cells and appears to stimulate cardiac angiogenesis and vasculogenesis in a paracrine way. Recombinant SDF-1/CXCL12 or recombinant vectors (e.g. plasmids) encoding SDF-1/CXCL12 have been developed for the treatment of peripheral arterial disease (PAD) in preclinical and clinical trials.
A phase I clinical trial (NCT01082094) showed no significant safety concerns related to gene transfer of a DNA plasmid encoding human SDF-1.
Yaohai Bio-Pharma Offers One-Stop CDMO Solution for SDF-1
SDF-1 Pipelines
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Generic Name
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Brand Name/
Alternative Name
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Indications
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Manufacturer
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Latest Stage
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JVS-100
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GP51801
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Peripheral arterial disease, Heart failure, Peripheral ischemia, Perioperative ischemia, Surgical wounds, Fecal incontinence
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Nanjing Jiqun Biotechnology, Juventas Therapeutics.
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Phase II
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4P-021
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Pending update
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novel coronavirus infection
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4P-Pharma
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Phase II
|
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AD-214
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Pending update
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Gastroesophageal Reflux, Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease
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AdAlta Ltd., Addpharma.
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Phase I
|
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CK-0804
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Pending update
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primary myelofibrosis
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Cellenkos.
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Phase I
|
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MB-1707
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Pending update
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Breast Cancer, Non-Small Cell Lung Cancer, Ovarian Cancer, Pancreatic Cancer, Solid Tumors
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Mainline Biosciences.
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Phase I
|
|
Auto immune disease therapy
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Pending update
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autoimmune disease
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Ermium Therapeutics SAS
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Pre-clinical
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GP 01CR11
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Pending update
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tumor
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GPCR Co., Ltd.
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Pre-clinical
|
|
GP-01CR21
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Pending update
|
tumor
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GPCR Co., Ltd.
|
Pre-clinical
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