Overview of Serum Albumin
Seerumi albumiini nimetatakse tavaliselt verealbumiiniks. See on albumiin (teatud tüüpi globulaarne valk), mida leidub selgroogsete veres. Albumiinid esinevad tavaliselt vereplasmas ja selle erinevus teistest verevalkudest seisneb selles, et need ei ole glükosüülitud. Inimese seerumi albumiini kodeerib geen ALB, samas kui teistel imetajate vormidel, näiteks veise seerumi albumiinil, on sarnased keemilised omadused.
Kui puudub albumiin kui oluline aine onkootilise rõhu säilitamiseks, mis on vajalik kehavedelike õigeks jaotumiseks veresoonte ja kehakudede vahel, sunnib kõrge rõhk veresoontes rohkem vedelikku kudedesse välja. Seoses mittespetsiifiliselt mitme hüdrofoobse steroidhormooniga, võib see toimida plasmakandjatena ja kasutada ka hemiini ja rasvhapete transportvalguna. Liigne või ebapiisav ringlev seerumi albumiin võib olla kahjulik.
Seerumi albumiin on imetajatel laialt levinud.
Human serum albumin (HSA) is a type of serum albumin found in human blood. As the protein with the highest content in human plasma, it accounts for about half of serum protein. It is also a highly water-soluble globular monomeric plasma protein. Its relative molecular weight of 67 KDa, and its composition consists of 585 amino acid residues, one sulfhydryl group and 17 disulfide bridges.
Bovine serum albumin (BSA or "Fraction V") is a type of serum albumin derived from cows that is often used as a protein concentration standard in laboratory experiments. The precursor polypeptide of BSA has a total length of 607 amino acids and18-residue signal peptide at the N-terminus. Another 6 amino acids are cleaved to produce mature BSA protein containing 583 amino acids.
Feline serum albumin (FSA) is a type of albumin derived from cats. It contains single polypeptide with 584 amino acids. According to reports, FSA has high sequence homology with canine serum albumin (CSA), while its dynamic changes are similar to those of HSA and BSA.
Canine serum albumin (CSA) is a type of albumin derived from dog. It contains single polypeptide with 584 amino acids. It is suitable for treating hypovolemic shock or hypoalbuminemia, regardless of its etiology. Canine albumin treatment applies to dogs.
Rekombinantne seerumi albumiin
Although serum albumin is purified from the blood of humans, cows, and other animals, the use of products derived from animals still has disadvantages such as immunogenicity, difficulty in obtaining sufficient supply, and contamination risks. The advancement of recombinant DNA technology has made it possible for microorganisms to produce various types of serum albumin, such as HAS, BSA, FSA, and CSA. Illustrative examples of the microbial host include bacterial (Escherichia coli, Bacillus subtilis), and yeast (Pichia pastoris, Saccharomyces cerevisiae).
Yaohai Bio-Pharma pakub ühekordset CDMO-lahendust rekombinantse albumiini jaoks
- Mikroobitüvede projekteerimine ja sõelumine
- Mikroobirakkude pangandus (PCB/MCB/WCB)
- Ülesvoolu protsesside arendamine
- Protsessi edasiarendus
- Formulatsiooni arendamine
- GMP tootmine
- Täida ja lõpeta
- Analüütiline ja testimine
- Regulatiivküsimused
EN
AR
HR
CS
DA
NL
FI
FR
DE
EL
IT
JA
KO
EI
PL
PT
RO
RU
ES
SV
IW
ID
LV
LT
SR
SK
SL
UK
VI
ET
HU
TH
TR
FA
AF
MS
BE
MK
KA
UR
BN
