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Brain-derived neurotrophic factor (BDNF)

Brain-derived neurotrophic factor (BDNF) Malaysia

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Modality

Brain-derived neurotrophic factor (BDNF)

Brain-derived neurotrophic factor (BDNF) is a growth factor that is encoded by the human BDNF gene. It belongs to the neurotrophin family and is structurally similar to the nerve growth factor (NGF).

BDNF mainly acts on neurons expressing tyrosine kinase B (TrkB) in the central and peripheral nervous system. It helps in maintaining the survival of existing neurons, and also promotes the growth and differentiation of new neurons and synapses.

BDNF is also essential for long-term memory and regulates glucose and energy metabolism, preventing the exhaustion of β cells. Neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, multiple sclerosis, and Huntington's disease are associated with decreased levels of BDNF. Recombinant BDNF, BDNF gene therapy or BDNG agonists may be useful in the prevention and treatment of these diseases.

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BDNF Pipelines

Name

Brand Name/ Alternative Name

Indication

Company

R&D Stage

Brain-derived neurotrophic factor

Growth factor

Amyotrophic lateral sclerosis (ALS)

The Max Planck Institute

Phase II

PG-003

BDNF Alternative Peptide

Central Nervous System Diseases

Peptigrowth, Inc.

Pre-clinical

BDNF gene therapy

Pending update

Glaucoma

Nippon Medical School, Teika Seiyaku KK

Pre-clinical

QTA-020V

AAV-vector therapy

Glaucoma

Astellas Pharma, Quethera Ltd.

Pre-clinical
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