All Categories
ENEN
Insulin Glargine, Recombinant

Insulin Glargine, Recombinant Indonesia

Home >  Modality  >  Proteins  >  Insulin for Human  >  Insulin Glargine, Recombinant

Modality

Insulin Glargine, Recombinant

Description of Insulin Glargine, Recombinant

Insulin glargine is the first long-acting basal insulin (once daily injection). It is a human insulin variant with three site differences: one amino acid substitution Gly(A21), and two arginines (Arg) added at the C-terminal of the B chain.

Insulin glargine was developed by Sanofi and approved in 2000 for diabetes mellitus. Recently, available insulin glargines include Lantus (Sanofi), Toujeo (Sanofi), Basaglar (Lilly), Rezvoglar (Lilly), and Semglee (Mylan).

 

Synonyms

GLA-100, GLA-300, HOE-71GT, HOE-901, Insulin Glargine (Genetical Recombination), Lantus, Lantus Solostar, Lantus XR, Optisulin, Toujeo, 来得时, 来优时, ランタス, Basaglar, Abasaglar, Rezvoglar, 优泌安,インスリン グラルギン(遺伝子組換え), Abasria

 

Amino Acid Sequence of Insulin Glargine

Insulin glargine differs from native human insulin at one amino acid of the A chain [Gly(A21)], and two amino acids at the C-termini of the B chain (Arg-Arg added).

Fig 1. Structure formula of insulin glargine

 

Expression System of Insulin Glargine

Brand Name

Active Substance

Expression System

Lantus (Sanofi)

Insulin Glargine

Bacteria (Escherichia coli)

Toujeo (Sanofi)

Insulin Glargine

Bacteria (Escherichia coli)

Basaglar (Lilly)

Insulin Glargine

Bacteria (Escherichia coli)

Rezvoglar (Lilly)

Insulin Glargine

Bacteria (Escherichia coli)

Lusduna (Merck)

Insulin Glargine

Bacteria (Escherichia coli)

Semglee (Mylan)

Insulin Glargine

Yeast (Pichia pastoris)

 

Formulation of Insulin Glargine

Inactive ingredients (Excipients) in Lantus (Vial, Prefilled Cartridge)

Zinc, m-cresol, glycerol 85%, polysorbate 20 (PS20) only in vial, and hydrochloric acid or sodium hydroxide (pH 4.0)

Inactive ingredients (Excipients) in Toujeo (Prefilled Pen, Cartridge)

Zinc, m-cresol, glycerol 85%, and hydrochloric acid or sodium hydroxide (pH 4.0)

Inactive ingredients (Excipients) in Basaglar (Prefilled Pen, Cartridge)

Glycerin, metacresol, zinc oxide, and hydrochloric acid or sodium hydroxide (pH 4.0)

Inactive ingredients (Excipients) in Rezvoglar (Prefilled Pen, Cartridge)

Glycerin, metacresol, zinc oxide, and hydrochloric acid or sodium hydroxide (pH 4.0)

Inactive ingredients (Excipients) in Semglee (Vial, Prefilled Pen/Cartridge)

Glycerol 85%, zinc, m-Cresol, polysorbate 20 (PS20) only in vial, and hydrochloric acid or sodium hydroxide (pH 4.0)

Inactive ingredients (Excipients) in Lusduna (Prefilled Pen, Withdrawn)

Glycerol, zinc chloride, metacresol, hydrochloric acid or sodium hydroxide (pH 4.0)

 

Yaohai Bio-Pharma offers One-Stop CDMO Solution for Insulin

 

Get a Free Quote

Get in touch