CRISPRCas9 mRNA

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  The potential applications of CRISPRCas9 mRNA

  AAV Plasmid Manufacturing can do many cool things! For example, it will be good for treating “genetic diseases” which are in fact diseases caused simply by errors in our genes. Examples of these diseases are sickle cell anaemia, Huntington's disease and cystic fibrosis. Well, these are some major health diseases which can let a person even die. Scientists can use CRISPRCas9 mRNA to correct the genetic errors responsible for these diseases. This technology is not just for making people better, but also for helping scientists to create seeds and animals that are of lesser quality. Farmers can produce work more durably crops or raise animals that are more resilient, as a result. That is because, not only can we grow plants which need less water or plants which pests can no longer eat to protect our environment by using CRISPRCas9 mRNA.

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  CRISPRCas9 mRNA- a revolutionary tool for treating genetic disorders

  We can now discuss more how CRISPRCas9 mRNA overcome the diseases. This is its main advantage and why it is such a powerful tool — essentially, with RNAi, we can go after the root cause of specific genetic issues. Each disease owes its existence to at least one root cause, and generally that root cause is a mutation in the DNA. Scientists can use this technology to make precise alterations in the DNA. This allows them to repair flaws that lead to sickness and ensure our bodies function better. And what if you could repair a broken toy. Well, scientists are essentially doing the same thing with CRISPRCas9 mRNA… but they are fixing our genetic “toys”!

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  Advantages and challenges of using CRISPRCas9 mRNA in gene therapy

  CRISPRCas9 mRNA has lots of advantages, for example it is very precise so patients suffering the same diseases could all be saved. However, they are not without their challenges for scientists. The modified genes also have to be safe, in that they cannot lead to unforeseen side effects. I think the former is far more vital, because we want to contribute or inspire to improve rather than cause negative reactions. But scientists still have to develop ways of delivering CRISPRCas9 mRNA to our cells. Delivering this to the right mailbox, basically. They also need to control how it behaves once inside cells to ensure it operates as intended, the researchers write.

Why choose Yaohai CRISPRCas9 mRNA?

• Tilpasning, effektivitet og omkostningseffektivitet

  CRISPRCas9 mRNA has experience in manufacturing biologics that are that are derived from microorganisms. We provide tailored RD as well as manufacturing solutions, while minimising the risk. We have experimented with a variety of techniques, such as recombinant cellular subunits of vaccines (including peptides), growth factors, hormones and the cytokines. We have specialized in multiple microorganisms like yeast extracellular and intracellular secretion (yields up to 15g/L) and bacteria intracellular soluble and inclusion bodies (yields up to 10g/L). We also have the BSL-2 fermentation platform to develop bacterial vaccines. We are experts in improving processes, increasing product yields, and decreasing production costs. With an effective technology team, we ensure timely and quality project delivery and bring your products to market faster.

• Kvalitetssystem og overholdelse af global lovgivning

  Yaohai BioPharma is a Top 10 Microbial CDMO that incorporates quality control and CRISPRCas9 mRNA. We have developed a solid quality system that adheres to current GMP standards and regulatory requirements worldwide. Our regulatory team is knowledgeable on global regulatory frameworks to expedite biological launches. We make sure that production processes are traceable with high-quality products as well as complying with the rules of the US FDA and EU EMA. Australia TGA and China NMPA are also in compliance. Yaohai BioPharma successfully passed an on-site audit conducted by a Qualified Person from the European Union (QP) to examine our GMP process and manufacturing facility. We also successfully been through the initial certification audits of the ISO9001 Quality Management System and ISO14001 Environmental Management System.

• Robust forsyningskæde og produktionskapacitet

  Yaohai Bio-Pharma, a top 10 producer of CRISPRCas9 mRNA, specializes in microbial fermentation. We have set up a modern facility with advanced facilities as well as robust RD manufacturing capabilities. Five production lines for drug substances complying with GMP standards for microbial purification and ferment along with two automated fill and finish lines for vials as well as cartridges as well as pre-filled needles are readily available. The available fermentation scales range between 100L and 2000L. Vial filling specifications cover 1ml - 25ml. the pre-filled cartridge or syringe filling specifications are between 1-3ml. The production workshop is cGMP certified and offers the availability of commercial and clinical samples. Our plant produces big molecules that are exported to all over the world.

• Professionel ekspertise og bred erfaring

  Yaohai Bio-Pharma is a leading microbiological CDMO. Our focus has been on microbially produced CRISPRCas9 mRNA and vaccines for human, veterinary and the management of pet health. We have state-of-the-art RD platforms and manufacturing methods which cover the entire procedure starting with microbial strain creation and cell banking, to process and method development to commercial and clinical production and implementation of cutting-edge solutions. Over the years we have gained vast expertise in bio processing using microbial sources. We have successfully delivered over 200 projects across the globe and have assisted our clients with navigating the regulations from the US FDA, EU EMA, Australia TGA, and China NMPA. We are able to react rapidly to market requirements and offer a customized CDMO services due to our expertise and knowledge.

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