Type XVII Collagen

Type XVII Collagen

Modality

Type XVII Collagen (Col XVII)

The transmembrane protein collagen XVII (Col XVII, COL17, BP180, BPAG2) is a structural element of hemidesmosomes (HD). Col XVII is a trimer whose C-terminal extracellular domains include collagen-like repeats that are arranged in a triple helical coil. Interestingly, COL17 normally acts by modulating stem cells and has been implicated in anti-aging and wound repair. Deficiency of COL17 leads to premature hair decay phenotypes and junctional epidermolysis bullosa.

Sources of Type XVII Collagen (Col XVII)

Col XVII or fragments of Col XVII have been reported to be produced in Escherichia coli (E. coli), yeast and other expression systems.

Applications of Type XVII Collagen (Col XVII)

During skin aging, COL XVII positively affects the stem cell niche of epidermal stem cells (ESCs), hair follicle stem cells (HFSCs), and melanocyte stem cells (MSCs), and COL17 is involved in ESC population dynamics and motility during skin wound recovery.

Also, COL17A1 was shown to effectively protect hair follicle stem cells (HFSCs) against follicular atrophy, hair loss and skin thinning, suggesting its potential application in hair regeneration.

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