Human Insulin, Recombinant

Modality

Human Insulin, Recombinant

Description of Human Insulin, Recombinant

Recombinant insulin human, identical to natural insulin from humans, is a short-acting/fast-acting human insulin produced by recombinant DNA technology. Since 1983, there have been several licensed products based on recombinant human insulin, including Humulin R (Lilly), Novolin R (Novo Nordisk), and Insuman Rapid (Sanofi).

Synonyms

Human Insulin, insulin human recombinant, Humulin R, Novolin R, Insuman Rapid

Amino Acid Sequence of Human Insulin

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Fig 1. Structural formula of Novolin R

Expression system of Human Insulin

Typical Products	Active Substance	Expression System
Humulin R	Recombinant insulin human	Bacteria (Escherichia coli)
Novolin R	Recombinant insulin human	Yeast (Saccharomyces cerevisiae)
Insuman Rapid	Recombinant insulin human	Bacteria (Escherichia coli)

Formulation of Humulin R, Novolin R, and Insuman Rapid

Inactive ingredients in Humulin R

Glycerin, metacresol (2.5 mg), endogenous zinc, and water for Injection.

Inactive ingredients in Novolin R

Glycerin, metacresol (3 mg), zinc, and water for Injection.

Inactive ingredients in Insuman Rapid

Metacresol, sodium dihydrogen phosphate dihydrate, glycerol, sodium hydroxide, hydrochloric acid (for pH adjustment), and water for injections.

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Human Insulin, Recombinant

Modality