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Diagnostic Reagents

Diagnostic Reagents

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Diagnostic Reagents

Microbial-produced biologics are used as diagnostic reagents for the target protein, antigen and antibody assay.

Labeled VHHs/sdAbs/nano-antibodies or antibody fragments, as in vivo diagnostics, are being studied in clinical trials for target-positive tumor diagnosis, such HER2, PD-1, MMR, CD38, CD8, CD206. VHHs or antibody fragments, as an alternative to antibodies, can also be used as in vitro diagnosis for antigen testing.

Besides, virus or bacterial recombinant antigens can be used in immunoassay kits for immunoglobulin M (IgM) antibodies and IgG tests. For example, recombinant HBcAg and HBsAg produced in Escherichia coli are involved in Anti-HBs Assay Kit; anti-HCV kit includes recombinant HCr43 protein, c100-3, and NS5-SOD produced in E.coli or yeast. Other commercial kits include anti-HEV, anti-HIV-1/HIV-2, anti-HTLV, anti-HCMV assay, and so on.

Yaohai Bio-Pharma provides CRDMO solutions for VHHs/sdAbs/nano-antibodies, antibody fragments, and antigens, based on microbial fermentation systems, e.g., bacteria (E. coli), yeast (Pichia pastoris, Saccharomyces cerevisiae, Hansenula polymorpha).

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