mRNA Vaccines for Cancer Therapy

Modality

mRNA Vaccines for Cancer Therapy

Currently, cancer vaccines have been given great expectation to be a possible therapy for cancer treatment due to their specificity, safety, and tolerability. mRNA cancer vaccine contains three critical components: antigen and adjuvant for immune stimulation, and drug delivery system. mRNA cancer vaccines deliver mRNA encoding anticancer antigens to host cells (usually antigen-presenting cells (APC)), causing them to express the target protein antigens, and then the major histocompatibility complex (MHC) is presented on the surface of the APC, resulting in the desired immune response.

There are some mRNA-based vaccines encoding Tumor Associated Antigens (TAA) and Tumor Specific Antigens (TSA) are in clinical trials in patients with lung cancer, colorectal cancer, melanoma cancer, head and neck cancer, renal cancer, liver cancer, glioma, or solid cancer.

Yaohai Bio-Pharma Offers One-Stop Solution for RNA

Catalog RNA Products

Catalog mRNA Products
Catalog saRNA Products
Catalog circRNA Products

Custom RNA Synthesis

Custom mRNA Synthesis
Custom saRNA Synthesis
Custom circRNA Synthesis

mRNA CDMO Services

Process Development
GMP Manufacturing
Aseptic Fill and Finish
Analysis and Testing

Custom Deliverables

Grade	Deliverables	Specification	Applications
non-GMP	Drug Substance, mRNA	0.1~10 mg (mRNA)	Preclinical research such as cell transfection, Analytical method development, Pre-stability studies, Formulation development
	Drug Product, LNP-mRNA
GMP, Sterility	Drug Substance, mRNA	10 mg~70 g	Investigational new drug (IND), Clinical trial authorisation (CTA), Clinical trial supply, Biologic license application (BLA), Commercial supply
	Drug Product, LNP-mRNA	5000 vials or pre-filled syringes/ cartridges

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mRNA Vaccines for Cancer Therapy

Modality