Growth Hormone (Porcine)

Modality

Development of Porcine Growth Hormone

Growth hormone, also known as somatotropin, plays an important role in normal growth, development, and overall health in animals, including humans and bovines. Porcine growth hormone (pGH), or porcine somatotropin (pST), is a single chain of 190 amino acids. In some countries, recombinant pST (rpST) analogues such as Reporcin, Grolene, and Somagrepor have been approved to increase muscle growth and decrease fat deposition in growing pigs. Thanks to recombinant DNA technology, large quantities of rpST can be produced at a lower cost.

Sequence Characteristics of Different rpST Analogues

Reporcin, Grolene, and Somagrepor are types of rpST analogues developed using genetic DNA technology. They consist of 191, 183, or 193 amino acids respectively. Reporcin has an extra methionine (Met) added to the N-terminus upstream of phenylalanine (Phe). Grolene is a zinc complex of porcine somatotropin (8-190), which is produced through genetic modification and lacks the first seven amino acids (Phe-Pro-Ala-Met-Pro-Leu-Ser-) at the N-terminal. Somagrepor, on the other hand, has an additional three amino acids (Met-Asp-Gln) at the N-terminus and four amino acid substitutions.

rpST based Products	pST Variants	Manufacturer
Reporcin	Extra Met at the N-terminal of porcine somatotropin	Zamira Life Sciences
Grolene	Porcine somatotropin (8-190)	Pitman-Moore
Somagrepor	Extra Met-Asp-Gln at the N-terminal and A3T, S8R, C181N, C189N mutations	Cyanamide Company

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Growth Hormone (Porcine)

Modality