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Monoclonal Antibodies Production in E. coli: Advances and Prospects

Jan 16, 2025

Monoclonal antibodies (mAbs), which are soluble glycoproteins of approximately 150 kDa consisting of heavy and light chains, are widely used in the treatment of cancers and autoimmune diseases. In recent years, the production methods of mAbs and thei...

Universal mRNA Vaccines: Combating Influenza for Global Health
Jan 15, 2025
Influenza viruses, particularly types A and B, annually trigger global health crises and economic losses. Their high mutation rate and ability to undergo genetic recombination make traditional vaccines difficult to provide long-term protection. In re...
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Production and Purification of Interferon
Jan 14, 2025
In modern medicine, biopharmaceuticals have brought significant breakthroughs in treating diseases. Interferon (IFN) is a key autocrine and paracrine protein that exhibits broad therapeutic efficacy against various conditions. IFN has a tremendous im...
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Harnessing Bacterial IBs for Recombinant Protein Production
Jan 09, 2025
Bacterial inclusion bodies (IBs) in recombinant protein production offer ease of separation, stability, high expression, and degradation resistance, and can express toxic proteins with biological activity. Advances in IB understanding open new avenue...
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VLPs Improve Treatment for Acute Myeloid Leukemia
Jan 07, 2025
Abnormal proliferation of myeloid progenitor cells in the bone marrow, peripheral blood, or extramedullary tissues leads to Acute Myeloid Leukemia (AML), a common form of leukemia in adults, with poor prognosis in elderly patients. Researchers from t...
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The Rise of Synthetic Biostructural Proteins
Jan 02, 2025
Biostructural proteins naturally evolved macromolecules like silk fibroin, elastin, and collagen, boast exceptional mechanical properties, biocompatibility, and degradability. Their hierarchical assembly capabilities allow the formation of advanced m...
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The Rise and Promise of Cell and Gene Therapy
Dec 19, 2024
Cell and Gene Therapy (CGT) is a cutting-edge medical approach encompassing both gene and cell therapy. Gene therapy aims to cure diseases by adding, modifying, or silencing individual genes' expression or repairing abnormal genes. Cell therapy, on t...
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Revolutionary Fusion Protein Technologies
Dec 17, 2024
Currently, many therapeutic proteins that have formed market scale are based on fusion protein technology. Fusion proteins utilize genetic engineering and other techniques to combine functional proteins with fusion partners, thereby enhancing their a...
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Cancer Therapy with Nanobody-Drug Conjugates
Dec 12, 2024
Chemotherapy, although widely employed in cancer treatment, is accompanied by significant side effects. Antibody-drug conjugates (ADCs) have shown promising therapeutic effects, but their large molecular weight restricts tissue penetration. Consequen...
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Unlocking the Secrets of High-Quality Plasmid Extraction
Dec 11, 2024
Plasmid extraction is crucial for researchers. As gene vectors, plasmids are vital in vaccine research and gene therapy, where quality matters. Key quality factors include supercoiled proportion and endotoxin content. Regulations vary: FDA ≥80%, S...
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Nanobodies: The Arising Star in Breast Cancer Treatment
Dec 05, 2024
Nanobodies exhibit unique advantages in breast cancer treatment due to their small size, high stability, and low immunogenicity. They can rapidly penetrate tumor tissues and effectively exert their therapeutic effects, while also being relatively low...
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Innovative Assembly Techniques for Large-Scale Gene Synthesis
Dec 04, 2024
The assembly technology for synthesizing large DNA fragments from scratch is the cornerstone of gene synthesis, encompassing methods such as BioBrick™, TAR, BglBrick, Golden Gate, Gibson assembly, CPEC, and Overlap PCR. Due to the limitations o...
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Selective Modifications for eGFP Reporter mRNA
Dec 03, 2024
When enhancing the performance of eGFP reporter mRNA, choosing the right nucleotide modifications is crucial. A strategic approach involves considering both the biological context and the specific experimental goals. The cell type and environment&nbs...
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Harnessing the power of VLPs for Allergy Treatment
Dec 02, 2024
Allergy is a prevalent disease, and VLPs in immune engineering offer new treatment options. VLPs, made of viral capsids without genetic material, are highly immunogenic, modulate immunity efficiently, and are low in allergenicity. For food allergies,...
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Enhancing eGFP Reporter mRNA with Nucleotide Modifications
Nov 28, 2024
In the advancing frontier of synthetic biology, nucleotide modifications have emerged as a powerful tool to enhance the performance of reporter mRNAs, such as those encoding enhanced green fluorescent protein (eGFP). These modifications not only impr...
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Why Use eGFP Reporter mRNA as a Control?
Nov 27, 2024
In the realm of molecular biology and gene expression studies, enhanced green fluorescent protein (eGFP) reporter mRNA has become a cornerstone for experimental controls. Its utilization stems from several compelling reasons. Firstly, fluorescent mar...
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VLPs: Pioneering Prevention in Infectious Diseases & Cancer
Nov 26, 2024
Virus-like Particles (VLPs) bridge nanotechnology, immunology, and synthetic biology, pivotal in preventing and treating infectious diseases and cancer. With years of CDMO experience, Yaohai Bio-Pharma excels in recombinant protein vaccine developmen...
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Pros and Cons of eGFP Reporter mRNA
Nov 25, 2024
Enhanced green fluorescent protein (eGFP) reporter mRNA has emerged as a powerful tool in biological research due to its distinct advantages. However, like any other technology, it also has limitations. Advantages: High Sensitivity and Ease of Detect...
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Unveiling the Optimal Dosage of eGFP Reporter RNA
Nov 22, 2024
In molecular biology and biotechnology, enhanced green fluorescent protein (eGFP) has emerged as a pivotal reporter gene due to its ability to produce bright green fluorescence at 509 nm. This protein, originally isolated from the jellyfish Aequorea ...
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Manufacturing Process of eGFP mRNA
Nov 21, 2024
The production of eGFP (Enhanced Green Fluorescent Protein) mRNA involves a series of molecular biology techniques to generate a functional RNA molecule that encodes for the expression of the eGFP. In the area of eGFP mRNA, Yaohai Bio-Pharma has accu...
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