Article-Yaohai Biopharmaceutical Co., Ltd.

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VLP Vaccine: A Novel Approach to Combat Mosquito-Borne Viruses

Feb 19, 2025

Virus-like particles (VLPs), non-infectious proteins mimicking viruses, are crucial in vaccine development. Texas Tech University researchers created a multivalent VLP vaccine targeting Chikungunya (CHIKV), Japanese Encephalitis (JEV), Yellow Fever (...

Quality Control and Applications of Recombinant Proteins
Feb 18, 2025
Quality control of recombinant proteins is crucial for the reliability and reproducibility of experimental data. Every step, from project design to production process, requires stringent quality control strategies. Quality Control Strategies The indu...
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Plasmid: A Small Circular DNA Molecule with Big Potential
Feb 14, 2025
Plasmids, small circular DNA molecules, serve as essential vectors for DNA recombination in molecular biology research and gene therapy. The yield and quality of plasmids are crucial, with supercoiled proportion and endotoxin content being two signif...
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Optimizing the Purification Process for Recombinant Human Insulin
Feb 13, 2025
In recent years, diabetes patient growth has driven insulin demand, but affordable insulin is in short supply. Efficient, economical insulin production is crucial. Mainly produced via Escherichia coli (E. coli) and yeast due to rapid growth and low c...
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Yeast cells for recombinant protein production
Feb 12, 2025
Traditional methods for acquiring pharmaceutical raw materials, such as plant extraction or relying on natural organisms, face challenges like long growth cycles and limited yields. Microbial recombinant protein synthesis technology, particularly usi...
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Optimizing E. coli Cellular Integrity for Biopharma Production
Feb 06, 2025
In the field of biopharmaceuticals, Escherichia coli (E. coli) plays a vital role as a host for the expression of recombinant proteins. The cellular integrity of E. coli is crucial for protein yield, quality, and production costs. This integrity prim...
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Codon Optimization Strategies
Feb 05, 2025
There are 64 genetic codons, of which 60 encode 20 amino acids. Every organism used for protein expression or production (including Escherichia coli, yeast, mammalian cells, Pichia, plant cells, and insect cells) exhibits some degree of difference or...
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Overcoming Challenges in Therapeutic Protein Purification
Jan 23, 2025
In recent decades, recombinant proteins have proven crucial in combating various diseases, demonstrating great potential. With advancements in genetic engineering, significant breakthroughs have been made in protein drug research. Technologies like f...
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IVT mRNA Preparation
Jan 22, 2025
In vitro transcription (IVT) is the preferred method for preparing mRNA, capable of yielding micrograms to milligrams of mRNA on a laboratory scale. For research purposes, reagent suppliers have developed versatile IVT reaction systems suitable for m...
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Minicircle DNA: Unlocking Gene Therapy's Future
Jan 21, 2025
Gene therapy, as a cutting-edge therapeutic approach, brings new hope for numerous incurable diseases. Among them, minicircle DNA (mcDNA), serving as a non-viral DNA carrier, is gradually demonstrating its unique charm. Introduction of mcDNA mc...
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Monoclonal Antibodies Production in E. coli: Advances and Prospects
Jan 16, 2025
Monoclonal antibodies (mAbs), which are soluble glycoproteins of approximately 150 kDa consisting of heavy and light chains, are widely used in the treatment of cancers and autoimmune diseases. In recent years, the production methods of mAbs and thei...
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Universal mRNA Vaccines: Combating Influenza for Global Health
Jan 15, 2025
Influenza viruses, particularly types A and B, annually trigger global health crises and economic losses. Their high mutation rate and ability to undergo genetic recombination make traditional vaccines difficult to provide long-term protection. In re...
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Production and Purification of Interferon
Jan 14, 2025
In modern medicine, biopharmaceuticals have brought significant breakthroughs in treating diseases. Interferon (IFN) is a key autocrine and paracrine protein that exhibits broad therapeutic efficacy against various conditions. IFN has a tremendous im...
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Harnessing Bacterial IBs for Recombinant Protein Production
Jan 09, 2025
Bacterial inclusion bodies (IBs) in recombinant protein production offer ease of separation, stability, high expression, and degradation resistance, and can express toxic proteins with biological activity. Advances in IB understanding open new avenue...
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VLPs Improve Treatment for Acute Myeloid Leukemia
Jan 07, 2025
Abnormal proliferation of myeloid progenitor cells in the bone marrow, peripheral blood, or extramedullary tissues leads to Acute Myeloid Leukemia (AML), a common form of leukemia in adults, with poor prognosis in elderly patients. Researchers from t...
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The Rise of Synthetic Biostructural Proteins
Jan 02, 2025
Biostructural proteins naturally evolved macromolecules like silk fibroin, elastin, and collagen, boast exceptional mechanical properties, biocompatibility, and degradability. Their hierarchical assembly capabilities allow the formation of advanced m...
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The Rise and Promise of Cell and Gene Therapy
Dec 19, 2024
Cell and Gene Therapy (CGT) is a cutting-edge medical approach encompassing both gene and cell therapy. Gene therapy aims to cure diseases by adding, modifying, or silencing individual genes' expression or repairing abnormal genes. Cell therapy, on t...
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Revolutionary Fusion Protein Technologies
Dec 17, 2024
Currently, many therapeutic proteins that have formed market scale are based on fusion protein technology. Fusion proteins utilize genetic engineering and other techniques to combine functional proteins with fusion partners, thereby enhancing their a...
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Cancer Therapy with Nanobody-Drug Conjugates
Dec 12, 2024
Chemotherapy, although widely employed in cancer treatment, is accompanied by significant side effects. Antibody-drug conjugates (ADCs) have shown promising therapeutic effects, but their large molecular weight restricts tissue penetration. Consequen...
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Unlocking the Secrets of High-Quality Plasmid Extraction
Dec 11, 2024
Plasmid extraction is crucial for researchers. As gene vectors, plasmids are vital in vaccine research and gene therapy, where quality matters. Key quality factors include supercoiled proportion and endotoxin content. Regulations vary: FDA ≥80%, S...
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