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Non-recombinant DNA Technology

Non-recombinant DNA Technology

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Vaccine

Vaccines Based on Non-Recombinant DNA Technology

Vaccines work by controlled exposure to harmless whole-pathogens (viruses or bacteria) or specific antigens, which ensures that the immune system can adequately neutralize the pathogen when the organism is confronted with it.

There have been many technologies applied in vaccine development, including traditional non-recombinant technology (e.g., live attenuated vaccine, inactivated vaccine, polysaccharide vaccine, toxoid vaccine) and recombinant DNA technology (DNA vaccine, mRNA vaccine, recombinant subunit vaccine, VLP vaccine, etc.).

Based on our microbial fermentation systems (BSL-1 and BSL-2 level), Yaohai Bio-Pharma offers Process and Manufacturing Solutions for microbial pathogen-derived vaccines, as follows:

Technical Route

Our Business

Deliverables (intermediate/drug substance/drug product)

Services

Conjugate vaccines

Yes

DS or DP: Conjugate vaccines

e.g., Pneumococcal, meningococcal vaccines.

Intermediate: Carrier proteins

e.g., VLP, CRM197, tetanus toxin, etc.

Vaccines CRDMO services, including intermediates, drug substances (DS) or drug products (DP) 【GMP grade】

  • Research samples preparation;
  • Microbial cell banking;
  • Process development, such as fermentation, purification and formulation;
  • Analysis method development;
  • GMP manufacture of live bacteria, or extracted subunit (BSL-1/BSL-2 Laboratory);
  • Quality control of the products;
  • Regulatory affairs.

Live, attenuated vaccines (microbial)

Yes

DS or DP: Live, attenuated vaccines

e.g., BCG live, cholera vaccine live.

Inactivated vaccines (microbial)

Yes

DS or DP: Inactivated vaccines

e.g., human typhoid Salmonella Inactivated vaccine

Toxoid vaccines

Yes

DS or DP: Inactivated toxoid

e.g., Diphtheria, tetanus and pertussis toxin, etc.

Polysaccharide vaccine

Yes

DS or DP (adjuvant): Polysaccharide vaccine

e.g., Typhim Vi vaccine, pneumococcal vaccine.

Find more information on Vaccine Solutions  in Yaohai Bio-Pharma.

Yaohai Bio-Pharma Offers One-Stop Solution for Non-Recombinant Vaccine
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