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Toxoid Vaccine

Toxoid Vaccine

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Toxoid Vaccine

Certain bacteria induce disease by secreting toxins, such as tetanus and diphtheria. Inactivated toxins prepared by physical and chemical methods are the main active ingredients of toxoid vaccines. Toxoid vaccines retain the immunogenicity that activates the production of specific antibodies but do not cause disease symptoms.

Currently approved human toxoid vaccines include diphtheria and tetanus vaccines, and veterinary vaccines include multivalent Pasteurella toxoid and porcine pleuropneumonia Actinobacillus toxoid.

Yaohai Bio-Pharma has over a decade of microbial CDMO experience. Based on the Biosafety Level 1 (BSL-1) and Biosafety Level 2 (BSL-2) GMP workshop, we provide a one-stop solution for microbial strain development, fermentation, toxoid extraction and purification, and aseptic filling.

According to the customized needs of customers, we provide clients with toxoid drug substance (DS, API) or vaccine drug product (DP) that meet quality standards, as well as GMP production records and test reports.

Some Approved Toxoid Vaccines Are listed as Follows:

Application

Toxoid Name

Strain Type

Platform

Human

Diphtheria Toxoid (DT)

Corynebacterium Diphtheriae

Microbial fermentation systems

Centrifugation and homogenization equipments

High/low pressure chromatography systems

Conjugate reaction tank

Biosafety Level: BSL-2

GMP Quality System

Tetanus Toxoid (TT)

Clostridium Tetani

Veterinary

Multivalent Pasteurella Toxoid

Multivalent Pasteurella

Hemolysin Toxins ApxI, ApxII, Apxlll

Actinobacillus Pleuropneumoniae

Human and Veterinary

Other microbial-derived toxins (BSL-1, BSL-2)

Toxoid Vaccine Drug Product Process

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Deliverable

Grade

Deliverables

Specification

Applications

GMP

Drug substance

Bacteria derived toxin

Investigational new drug (IND),

Clinical trial authorisation (CTA),

Clinical trial supply,

Biologic license application (BLA),

Commercial supply

Drug product

Vials (liquid)

Vials (lyophilized)

Other dosage forms

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