Interferon-γ (IFN-γ)

Modality

Interferons (INFs) are cytokines secreted at the beginning of viral infection that have both antiviral and antiproliferative effects. As a class of human INFs, human recombinant interferon gamma (IFN-γ) has been approved to treat chronic granulomatous disease and osteoporosis and is increasingly likely to be used as a cancer immunotherapy.

As they do not require posttranslational manipulations to display biological activity, the recombinant INFs currently produced in Escherichia coli (E. coli) is in clinical practice.

Application of Interferon-γ (IFN-γ)

Being an interferon gamma, Actimmune (Interferon gamma-1b) is a single-chain polypeptide with 140 amino acids, which is produced by fermentation in genetically engineered E. coli bacterium that contains recombinant protein-coding DNA. The product is purified by conventional column chromatography and developed by Horizon Pharma.

Yaohai Bio-Pharma Offers One-Stop CDMO Solution for Interferon-γ (IFN-γ)

Interferon-γ (IFN-γ) Pipelines

Generic Name	Brand Name/ Alternative Name	Expression System	Indications	Manufacturer	R&D Stage
Recombinant human interferon γ-1b	Actimmune, Interferon gamma-1b, IFN-gamma-1b, Interferon gamma 1-b, Interferon gamma-1b, recombinant Interferon gamma-2a	Escherichia coli (E. coli)	Infection	Horizon Pharma	Approval
Injection - Recombinant human interferon γ	Gamma, 伽玛	E. coli	Rheumatoid arthritis; Liver fibrosis; Chronic granulomatous disease	Chemowanbang Biopharma	Approval
Interferon alpha-2b/interferon gamma	Interferon-gamma/interferon-alpha-2b, CIGB-128, CIGB-128-A	Pending update	Tumor, Infectious diseases	Heber Biotec SA	Phase II

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Interferon-γ (IFN-γ)

Modality