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H. influenzae protein D (HiD)

H. influenzae protein D (HiD)

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H. influenzae protein D (HiD)

Haemophilus influenzae protein D (HiD) is a strongly conserved 42 kDa surface lipoprotein presented in H. influenzae. Like tetanus toxin (TT) and diphtheria toxoid (DT), HiD were used as an antigenically active carrier protein in a 10-valent Streptococcus pneumococcal polysaccharide conjugate vaccine (Synflorix).

In Synflorix (GlaxoSmithKline), 10 serotypes of the Streptococcus pneumococcus (1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F) are bound to the carrier proteins HiD, TT or recombinant DT to form 10 polysaccharide vaccines. Of these, HiD (Protein D) is recombinantly manufactured in recombinant engineered Escherichia coli (E. coli) and used in eight of the ten serotypes (serotypes 1, 4, 5, 6B, 7F, 9V, 14 and 23F) as a carrier protein.

GSK received marketing authorization for Synflorix from the European Medicines Agency (EMA) in 2009.

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