Tumor Necrosis Factor (TNF-α)

Modality

Tumor Necrosis Factor (TNF-α)

There are two subtypes constituting tumor necrosis factor (TNF), α and β, with similar biological actions. The most frequently researched is TNF-α among these, also known as TNF, cachectin, macrophage cytotoxic factor, macrophage cytotoxin, or necrosin. Produced in Escherichia coli (E. coli), recombinant TNF has been approved as adjuvant for oncological surgery.

Application of TNF-α

Recombinant TNF-α-1a

Containing the active substance tasonermin (TNF-α-1, a tumor necrosis factor alfa-1a), Beromun is produced by recombinant DNA technology in E. coli. This is a drug known as an immunostimulant that helps the body's immune system combat cancer cells.

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TNF-α Pipelines

Generic Name

Brand Name/

Alternative Name

Expression System

Indications

Manufacturer

R&D Stage

tasonermin

Beromun, TNF-α -1a, FK 516, TNF alpha, TNF ALPHA-1A, nonglycosylated tumour necrosis factor alpha

Escherichia coli (E. coli)

Adjunct for surgery tumor removal; palliative care after irresectable soft tissue sarcoma of the limbs

Belpharma Sa, Genentech, Inc.

Approval

Tengonermin

Zaﬁride, ARENEGYR, CNGRC peptide-TNF alpha conjugate, NGR-TNF, NGR-TNFα, Tumour-homing-peptide-tumour-necrosis-factor-alpha-fusion-protein, Tumour-vasculature-targeted-tumour-necrosis-factor-alpha

Pending update

Malignant mesothelioma Orphan medicine

AGC Biologics SpA

Pending update

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Tumor Necrosis Factor (TNF-α)

Modality