The human body can be the utilized by mRNA to translate and encode therapeutic proteins like transmembrane, intracellular, intramitochondrial, and secreted proteins. mRNA-based protein replacement therapy provides a viable alternative cure for various diseases.
Clinical trials have demonstrated that mRNA-based therapeutics can be used in myocardial ischemia (AZD8601, VEGF mRNA), ornithine transcarbamylase deficiency (ARCT-810, OTCase mRNA), methylmalonic acidemia (mRNA-3705, MUT mRNA), propionic acidemia (mRNA-3927, PCCA/B mRNA), cystic fibrosis (MRT-5005 and VX-522, CFTR mRNA).
In addition, mRNAs directly encode antibodies (e.g., neutralizing antibodies, antibody fragments, and nano-antibodies) for the prevention and treatment of viral infections and cancer. These antibodies specifically recognize viruses, bacteria, and cancer /tumor cells and bind them via long variable chains, which turns out to be useful for the prevention and treatment of SARS-CoV-2, HIV, as well as animal models and human tumors.
Yaohai Bio-Pharma Offers One-Stop Solution for RNA
Custom Deliverables
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Grade
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Deliverables
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Specification
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Applications
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non-GMP
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Drug Substance, mRNA
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0.1~10 mg (mRNA)
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Preclinical research such as cell transfection, Analytical method development, Pre-stability studies, Formulation development
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Drug Product, LNP-mRNA
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GMP, Sterility
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Drug Substance, mRNA
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10 mg~70 g
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Investigational new drug (IND), Clinical trial authorisation (CTA), Clinical trial supply, Biologic license application (BLA), Commercial supply
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Drug Product, LNP-mRNA
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5000 vials or pre-filled syringes/ cartridges
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