Liraglutide

Liraglutide

Modality

Description of Liraglutide

Liraglutide is a biosynthetic GLP-1 analogue, with 97% amino acid residue identity to natural GLP-1 (7-37). Novo developed two formulations of liraglutide available in the market, i.e., Victoza and Saxenda for glycemic control (1.2-1.8 mg daily) and weight management (3 mg daily), respectively.

Synonyms

LATIN T1D, Liraglutide (Genetical Recombination), NEX 22, NN 2211, NN 9211, NN-8022, NNC 90-1170, SAXE, Saxenda, Victoza, 诺和力, ビクトーザ

Amino Acid Sequence of Liraglutide

The differences between Liraglutide and human GLP-1 (7-37) are that Lys is replaced by Arg at position 28; glutamate spacer at Lys in position 20 conjugates palmitic acid. Through binding to serum albumin and self-binding in the subcutaneous space, fatty acid conjugation prolongs the duration of action.

Fig.1 Structure formula of liraglutide

Expression System of Liraglutide

Yeast (Saccharomyces cerevisiae)

Some liraglutide biosimilars are produced in bacteria (Escherichia coli).

Formulation of Liraglutide

Inactive ingredients in Victoza/ Saxenda

Disodium phosphate dihydrate, 1.42 mg; propylene glycol, 14 mg; phenol, 5.5 mg; and water for injection.

Manufacturing Process of Liraglutide

Drug Substance Manufacturing

Yeast fermentation and culture broth harvesting
Purification to produce pure liraglutide precursor
Acylation of the liraglutide precursor and purification to produce drug substance.

Drug Product Manufacturing

Aseptic Fill-Finish: formulation preparation and filling into cartridges

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Liraglutide

Modality

Liraglutide

Description of Liraglutide

Synonyms

Amino Acid Sequence of Liraglutide

Expression System of Liraglutide

Formulation of Liraglutide

Manufacturing Process of Liraglutide

Drug Substance Manufacturing

Drug Product Manufacturing

Yaohai Bio-Pharma offers One-Stop CDMO Solution for Liraglutide

MICROBIAL CDMO

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