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Type I Collagen

Type I Collagen

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Modality

Type I Collagen (Col I)

Collagen type I (Col I) is the most predominant collagen in vivo, accounting for approximately 90% of all vertebrate collagen in the human body. Because of the Glycine-X-Y structure, the Col I gene itself forms a triple-helical conformation.

Type I collagen has two isomers: homotrimers and heterotrimers. The heterotrimer is the major isomer of collagen I and performs important roles in wound healing.

Sources of Type I Collagen (Col I)

Traditionally, collagen is derived from animals such as cattle, pigs, fish, amphibians and birds. In some cases, the use of animal-derived collagen has been restricted for safety and religious reasons. Therefore, recombinant DNA technology is an alternative strategy that provides the potential to be used as a biomaterial in the fields of tissue engineering, medical devices, pharmaceuticals and biomedicine.

Applications of Type I Collagen (Col I)

Medical Devices

Due to its biocompatibility, Col-I is widely used as a regenerative agent for nerve repair, bone reparation, chondrogenic fractionation, vascular grafts, and corneal substitutes. Several recombinant type III collagen are used in the chemical compound of injection, dressing, and spray to eliminate scars, reduce wrinkles, and improve skin condition as medical devices.

Cosmeceutical

Col-I is also widely used in the cosmetic industry to act as an anti-aging, skin revitalizing and dermal filler. In addition, Col-I is studied extensively as soft-tissue filler, chemical peels and laser hair reduction.

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