Truncated Plasmin

Truncated Plasmin

Modality

Therapeutic Use of Truncated Plasmin

Symptomatic vitreomacular adhesion (VMA) is a vision-threatening condition when the vitreous gel adheres unusually tightly to the retina, which leads to a variety of retinal abnormalities.

As non-specific serine protease, plasmin or truncated plasmin have been developed as nonsurgical enzyme therapeutics for treating symptomatic VMA. Plasmin directly or indirectly regulates the fibrinolysis and lysis of a variety of vitreous macromolecules. This approach can enable the proteolytic degradation of protein components (‘glue’ molecules) of the vitreous body and the vitreoretinal interface (e.g. laminin, fibronectin, and collagen) caused by VMA.

Ocriplasmin, also known as Jetrea or microplasmin, is a shortened recombinant form of human serine protease plasmin that is produced in an expression system in Pichia pastoris. It is composed of two peptide chains, each containing 19 and 230 amino acids, and has a molecular weight of 27.2 kDa.Ocriplasmin is developed for treating symptomatic VMA through selectively cleaving the peptide bonds at the C-termini of arginine (Arg) or lysine (Lys) residues.

Ocriplasmin (Jetrea) is now available in the US (FDA) and Europe (EMA). It is developed and commercialized by Oxurion (formerly ThromboGenics). In 2020, Inceptua obtained the global commercial rights to Jetrea from Oxurion NV.

Yaohai Bio-Pharma Offers One-Stop CDMO Solution for Truncated Plasmin

Truncated Plasmin Pipeline

Generic Name	Brand Name/ Alternative Name	Expression System	Indications	Manufacturer	R&D Stage
Ocriplasmin	Jejetrea, THR-409, A-01016, Jetrea	Yeast (Pichia pastoris)	Retinal disorders, Symptomatic vitreomacular adhesions, Diabetic retinopathy	Thrombogenics, Inc., Oxurion NV, Alcon AG	Approved
JZB-32	Recombinant human truncated plasmin	Pending update	Symptomatic vitreomacular adhesions, Polyp-like choroidal vascular disease	Chengdu Zeyan Biotechnology, Hefei Zeyan Biotechnology	Phase I
Ocriplasmin	GW005, Recombinant truncated human plasmin	Yeast	Symptomatic vitreomacular adhesions	Mabwell Bioscience	Pre-clinical

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Truncated Plasmin

Modality