GM-CSF

Modality

Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF)

Granulocyte-macrophage colony-stimulating factor (GM-CSF, CSF-2) and granulocyte colony-stimulating factor (G-CSF, CSF-3) belong to white cell factors (leukocyte growth factor) and perform important roles in neutrophil differentiation of hematopoietic stem cells.

As a hematopoietic growth factor, GM-CSF can promote the proliferation and differentiation of hematopoietic progenitor cells. And recombinant GM-CSF, including Molgramostim and Sargramostim, has received approval for the treatment of neutropenia.

Application of GM-CSF

Molgramostim

Produced using Escherichia coli expression system, molgramostim is a non-glycosylated protein and includes 127 amino acids with isoleucine at position 100 with a molecular weight of 14.5 kDa.

Sargramostim

Produced by recombinant DNA technology in a yeast (Saccharomyces cerevisiae), Sargramostim, is a recombinant human GM-CSF and a glycosylated protein consisting of 127 amino acids. Its amino acid sequence is different from that of human GM-CSF in that the arginine (Arg) at position 23 is replaced by a leucine (Leu).

Sargramostim (Leukine) was developed by Schering and Sanofi and is now marketed by Partner Therapeutics.

Yaohai Bio-Pharma Offers One-Stop CDMO Solution for GM-CSF

GM-CSF Pipelines

Name	Brand Name/ Alternative Name	Expression System	Indications	Manufacturer	R&D Stage
Sargramostim	LEUKINE	Saccharomyces cerevisiae	Neutropenia	BERLEX LABS, Partner Therapeutics, Inc., Bayer AG	Approval
Sargramostim biosimilar	Pending update	Pending update	Neutropenia	Emcure Pharmaceuticals Ltd.	Approval
Molgramostim	Pending update	Escherichia coli (E. coli)	Neutropenia	Schering-Plough Corp.	Approval
Molgramostim topical gel	金扶宁, 外用凝胶	E. coli	Burn	GenSci	Approval
Molgramostim biosimilar	吉洛因	Pending update	Neutropenia	Institute of Medical Biology	Approval
Molgramostim biosimilar	Pending update	Pending update	Neutropenia	bioMérieux SA	Approval
Molgramostim biosimilar	Pending update	Pending update	Neutropenia	Laboratorios AC Farma SA	Approval
Molgramostim biosimilar	Pending update	Pending update	Neutropenia	Probiomed SA de CV	Approval
Molgramostim biosimilar	特尔立	Pending update	Neutropenia	Amoytop	Approval
Molgramostim biosimilar	Pending update	Pending update	Neutropenia	AMEGA Biotech	Approval
Molgramostim biosimilar	Pending update	Pending update	Neutropenia	BioGeneric Pharma SAE	Approval
Molgramostim biosimilar	Pending update	Pending update	Neutropenia	Blau Pharmaceuticals	Approval
Molgramostim biosimilar	Pending update	Pending update	Neutropenia	Laboratorios Bioprofarma	Approval
Molgramostim biosimilar	Pending update	Pending update	Neutropenia	Reliance GeneMedix Ltd.	Approval
Molgramostim biosimilar	Pending update	Pending update	Neutropenia	Zenotech Laboratories Ltd.	Approval
Recombinant Human GM-CSF	健白	Pending update	Neutropenia	PKU HealthCare Corp	Approval
Recombinant Human GM-CSF	Gurning	Pending update	Neutropenia	HYBio	Approval
Recombinant Human GM-CSF	Pending update	Pending update	Neutropenia	Guangzhou Baiyunshan	Approval
Recombinant Human GM-CSF	金磊赛源	E. coli	Neutropenia	GenSci	Approval
Recombinant Human GM-CSF	Pending update	Pending update	Neutropenia	Sino Biopharma	Approval
Recombinant Human GM-CSF	Pending update	Pending update	Neutropenia	Changchun Institute of Biological Products	Approval
Recombinant Human GM-CSF	里亚尔	E. coli	Neutropenia	Hapharm	Approval
Recombinant Human GM-CSF	Pending update	Pending update	Neutropenia	Jiangzhong pharmaceutical	Approval
Recombinant Human GM-CSF	尤尼芬	Pending update	Neutropenia	Hainan unipul pharma	Approval
Recombinant Human GM-CSF	华北吉姆欣	Pending update	Neutropenia	North china pharmaceutical	Approval
Molgramostim inhalation	Pending update	Pending update	Neutropenia	Savara, Inc., Savara Pharmaceuticals, Y-mAbs Therapeutics, Inc.	phase III
Molgramostim biosimilar	Pending update	Pending update	Neutropenia	Zhejiang Zhongqi BioPharma	phase II
GX-G3	A recombinant human G-CSF fused to hyFc	Pending update	Heatic neutral granulocyte reduction caused by chemotherapy, Neutropenia	Boryung Corp., Ilkogen, Genexine, Inc.	phase II

All Categories

Modality

Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF)

Application of GM-CSF

Molgramostim

Sargramostim

Yaohai Bio-Pharma Offers One-Stop CDMO Solution for GM-CSF

GM-CSF Pipelines

MICROBIAL CDMO

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