mRNA Vaccines Against Virus Pathogens

Modality

mRNA Vaccines Against Virus Pathogens

mRNA vaccines against infectious viruses have shown promising results, and several products have been approved or have undergone human clinical trials.

The general steps in the development of such vaccines provide for 1) structuring of core antigens and optimization of the mRNA sequence; 2) selection of the appropriate combination of mRNA structure, adjuvants, delivery systems, and route of administration; 3) determination of the potency of the mRNA; and 4) study and demonstration of the mechanisms of immune induction.

Here we make a list of some promising mRNA vaccines against virus infections, including SARS-CoV-2 virus, Respiratory Syncytial Virus (RSV), Varicella Zoster Virus (VZV)/ Shingles, Inﬂuenza Virus, Cytomegalovirus (CMV), Venezuelan Equine Encephalitis Virus (VEEV), Rabies Virus (RABV), Zika virus (ZIKV), Human Immunodeficiency Virus (HIV), etc.

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Grade	Deliverables	Specification	Applications
non-GMP	Drug Substance, mRNA	0.1~10 mg (mRNA)	Preclinical research such as cell transfection, Analytical method development, Pre-stability studies, Formulation development
	Drug Product, LNP-mRNA
GMP, Sterility	Drug Substance, mRNA	10 mg~70 g	Investigational new drug (IND), Clinical trial authorisation (CTA), Clinical trial supply, Biologic license application (BLA), Commercial supply
	Drug Product, LNP-mRNA	5000 vials or pre-filled syringes/ cartridges

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mRNA Vaccines Against Virus Pathogens

Modality