Some may not be familiar with Phenylalanine Ammonia Lyase (PAL). PAL is a type of special protein known as an enzyme that's used in the production of various products. These products can be health foods, vitamins, and others. One company that produces PAL is known as Yaohai. They are extremely dedicated to providing quality pal and in this article we cover how they produce pal and how they can present pal in diverse fashions.
The first step in making PAL is to grow special cells that will produce it. Those cells need to be properly nurtured, and that means eating good food, such as sugar, proteins, and vitamins, so they can grow strong and healthy. It’s a little like planting a garden, you have to ensure that the plants have the right nutrients to sprout. Once the cells are large enough, we then add the PAL inducers. These are helper cells that stimulate the cells to create more PAL. These helpers must be safe for people to eat and use.
Now we have to harvest the cells and isolate the PAL from the remaining endproducts. We separate them using a technique known as chromatography. Chromatography is a nice techniques allow us to hold different component of a mixture separate. This serves as the mechanism through which we can isolate the PAL of choice from other unwanted matter. This step is important because we only want to have pure PAL in the end, the purest form.
Always working to refine their process producing PAL, Yaohai accompanies their testing of each new batch with a unique qr code on the label. They use new tools and tech to make the process faster and easier. One of the tools they use, for example, is a bioreactor. A bioreactor is a giant vessel that creates the optimal environment for the cells to develop. It gives the proper temperature and acidity, which is very essentials for cells to stay healthy and multiply PAL as much as possible.
PAL has great significance in various fields, from food to cosmetics, to medicine. In food, PAL manufactures health foods and vitamins. Health foods are foods that help people feel good and provide benefits, like reducing cholesterol. This is beneficial for heart well-being! Vitamins are essential for our body, help in keeping our body fit and healthy. PAL can convert a particular protein, known as phenylalanine, into another vital protein called tyrosine. Now why is tyrosine important? Because tyrosine is needed for the synthesis of many different compounds in our body.
In the cosmetics industry, PAL is used in the production of products with the ability to make the skin less irritated and radiate a better skin color. Ingredients made using PAL may be found in some creams and lotions used to treat skin problems, for example. In pharmaceuticals, PAL can facilitate the development of drugs aimed at combating life-threatening conditions such as cancer and Parkinson's disease. This demonstrates the significance of PAL in developing products that have health and beauty benefits.
PAL is a very important contributor in the health foods and vitamins. As previously stated, PAL converts phenylalanine to tyrosine. Tyrosine is an important protein that helps form a number of vital products in the body, including stress-regulating hormones and pigments that give skin its hue. PAL hydrogenates tyrosines, and we can help produce products that are good in taste and good for health.
Yaohai Bio-Pharma is a leading microbial biologics CDMO. Our main focus has been the production of Phenylalanine Ammonia Lyase (PAL) Manufacturing and therapeutics to treat pets, human and veterinary health. We have state-of-the-art RD platforms and manufacturing technology that cover the entire manufacturing process beginning with the development of microbial strains Cell banking, process and method development, through commercial and clinical manufacture that ensures the successful delivery of innovative solutions. Over time we've gained a vast knowledge of microbial-based bio processing. We have successfully completed more than 200 global projects, and help our clients with navigating the rules and regulations of the US FDA, EU EMA, Australia TGA, and China NMPA. We are able to react promptly to market demands and provide tailored CDMO services due to our experience and expertise.
Yaohai Bio-Pharma, a top 10 producer of biological products, is a specialist in microbial fermentation. We have established an advanced facility that is equipped with modern facilities and strong RD manufacturing capabilities. We have five drug substance manufacturing lines that are in compliance with GMP requirements for microbial fermentation and purification, as well as two fill-finish lines that are automated for cartridges, vials, as well as pre-filled syringes. The available fermentation scales vary from 100L to 500L, 1000L and 2000L. Phenylalanine Ammonia Lyase (PAL) Manufacturing for vias are 1ml to 25ml, whereas the pre-filled syringes and cartridge filling specifications cover 1-3ml. Our production workshop is cGMP compliant and guarantees steady supply of clinical samples as well as commercial items. Our plant produces large molecules which are shipped to the globe.
Yaohai BioPharma is a Top 10 Microbial CDMO that incorporates quality control and regulatory matters. We have a quality system which is in line with current GMP standards and international regulations. Our regulatory team is knowledgeable in global regulatory frameworks to accelerate biological launches. We ensure traceable manufacturing processes and top-quality products that are compliant with the requirements of the US FDA, EU EMA, Australia TGA, and Phenylalanine Ammonia Lyase (PAL) Manufacturing. Yaohai BioPharma has successfully passed the audit on site of the European Union's qualified Person (QP) for our GMP quality system and production site. In addition, we've cleared the first certification audits of the ISO9001 Quality Management System, ISO14001 Environmental Management System, and ISO45001 Occupational Health and Safety Management System.
Yaohai Bio-Pharma has experience in manufacturing biologics that are created from microorganisms. We offer bespoke RD solutions as well as manufacturing services while minimising potential risks. We have worked with diverse techniques, such as recombinant cellular subunits, vaccines (including peptides), growth factors, hormones, and the Phenylalanine Ammonia Lyase (PAL) Manufacturing. We are a specialist in many microorganisms like yeast extracellular and intracellular secretion (yields up to 15g/L) and bacteria intracellular soluble, and inclusion body (yields up to 10g/L). We have also developed a BSL-2 fermentation platform to create bacterial vaccines. We have a track record of improving production processes, thereby increasing yields and reducing costs. We have a highly-efficient technology team to ensure timely and high-quality delivery of projects. This helps us bring your products that are unique faster to the market.