I bet you did NOT know this-there are these microscopic little beings, think bacteria and yeast (like the stuff that helps make bread rise) -that can be used to help us feel better by making our medicines. It’s really fascinating! Medicines manufacturers use fermentation to produce powerful, life-saving treatments for common diseases.
Fermentation: a process through which nutrients or molecules are degraded because of fermentation, i.e. when small organisms are added to mixtures in order for them to grow and multiply. These nutrients are consumed by microorganisms, who in turn create special substances that have proven to be very useful for medicinal purposes. But here comes the question in mind, how do we take out these helpful substances from this mixture after fermentation? This is where a second essential step comes into place - purification.
To learn how fermentation actually works, we first have to understand proteins. Proteins are considered the building blocks of life because they consist of a long polymer chain and include amino acids. Proteins are the Lego blocks of your body, which is to say proteins help build muscles, skin and more importantly enzymes that digest our food.
A VLP resembles a virus, but there is no harm in it. Using genetics combined with fermentation, scientists make VLPs. It is somewhat akin to synthesizing a faux-virus that masks itself as the real thing, however cannot potentially cause you illness. This is crucial during the period so our bodies become morphed on how to identify and resist valid viruses.
VLPs have been suggested for assisting in the treatment of a wide array of diseases, ranging from cancer to influenza. By imitating viruses, they help our bodies practice recogninzing them and keeping us from becoming sick. This is so exciting because it gives us the tools to better ourselves in all these diseases that afflict such large parts of humankind.
But making VLPs is no easy feat. For this we have to make them in a way that they take the form of should and then only it could be used as medicine. And this is exactly where the art of Fermentation takes place. Nowadays, biopharmaceutical companies are producing VLPs on an unprecedented scale through fermentation, and aiming to produce treatments as affordable prices.
The first decision which scientists will have to make is about the microorganism they want for fermentation. They also have to identify which nutrients will help those microorganisms flourish and produce the ideal VLP. Just like picking the right ingredients for a recipe.
Yaohai Bio-Pharma, a leader in CDMOs of microbial biologics, is headquartered in Jiangsu. We have been focused on microbially produced therapeutics and vaccines that are suited for human, veterinary and the management of VLP Fermentation and Purification Process. We have the most the most advanced RD as well as manufacturing technology platforms, which cover the entire process from Microbial strain engineering, cell banking as well as process and method development to commercial and clinical manufacturing, assuring the successful supply of the most cutting-edge solutions. We have accumulated a huge amount of experience in the bio processing of microbial cells. We have delivered over 200 projects across the globe and have assisted our clients with navigating the rules and regulations of the US FDA, EU EMA, Australia TGA, and China NMPA. Our expert knowledge and vast experience enable us to swiftly adapt to market needs and offer tailored CDMO services.
Yaohai BioPharma is a Top 10 Microbial CDMO that incorporates quality control and regulatory matters. We have a quality system which is in line with current GMP standards and international regulations. Our regulatory team is knowledgeable in global regulatory frameworks to accelerate biological launches. We ensure traceable manufacturing processes and top-quality products that are compliant with the requirements of the US FDA, EU EMA, Australia TGA, and VLP Fermentation and Purification Process. Yaohai BioPharma has successfully passed the audit on site of the European Union's qualified Person (QP) for our GMP quality system and production site. In addition, we've cleared the first certification audits of the ISO9001 Quality Management System, ISO14001 Environmental Management System, and ISO45001 Occupational Health and Safety Management System.
Yaohai Bio-Pharma, a top 10 producer of VLP Fermentation and Purification Process, specializes in microbial fermentation. We have set up a modern facility with advanced facilities as well as robust RD manufacturing capabilities. Five production lines for drug substances complying with GMP standards for microbial purification and ferment along with two automated fill and finish lines for vials as well as cartridges as well as pre-filled needles are readily available. The available fermentation scales range between 100L and 2000L. Vial filling specifications cover 1ml - 25ml. the pre-filled cartridge or syringe filling specifications are between 1-3ml. The production workshop is cGMP certified and offers the availability of commercial and clinical samples. Our plant produces big molecules that are exported to all over the world.
Yaohai Bio-Pharma is experienced in the development of microbial-derived biologics We offer tailored RD solutions and manufacturing while keeping risks to a minimum We have used a variety of modalities including recombinant subunits vaccines (including peptides) growth factors hormones and Cytokines We've specialized in several microorganisms like yeast intracellular and extracellular secretion (yields up to 15g/L) and bacteria intracellular soluble and inclusion body (yields as high as 10g/L) We have also created a VLP Fermentation and Purification Process fermentation system to develop bacteria-based vaccines We are experts in optimizing processes increasing yields as well as reducing production costs Utilizing a strong technology team we ensure timely and quality project delivery to bring your exclusive products to market faster