To almost all of us, when you say "glow-in-the-dark," the first thing that comes to mind aren't even electromagnetic, as in fireflies or lightning bugs, those little insects that glow during warm summer nights. However, there are a number of other microorganisms that also have the ability to produce light. And some of these are even microscopic creatures in bacteria and fungi. This light is, in fact, a type of bioluminescence that they emits. This is due to a special molecule called Lucifer; It enables the creation of a new kind of bioluminescence that scientists just found out exists, made as it is involving a sort of genetic material called circRNA. I will cover this topic in more detail as it is a very cool and interesting one to get into!
The abbreviation circRNA means “circular RNA.” Assistant Professor of Biological Chemistry and Biomedical Engineering Michael RustWe often hear about RNA — that this, like DNA is a type of genetic material. In some cases, circRNA is produced by living organisms, such as various fungi that make glowing in the dark. Scientists, such as Dr. Liu Yaohai, have been researching how this works and have already made some progress in understanding the mechanisms behind it. An essential part of this glowing mechanism is the luminescent conversion of luciferin to its oxyluciferin glow state. This transformation is important because it enables the organism to produce light.
This is a game-changer in the science and medical fields, so the discovery of bioluminescent circRNA really excites us. In summary, circRNA could potentially be manipulated as a molecular modulator for altering gene expression and the development of novel Therapeutics against different diseases. For example, this might be really great for people who have conditions that are hard to manage and are in need of medical treatment. CircRNA can also help scientists to follow paths of cells as they move inside our body. They can utilize this feature to better understand diseases and how they are transmitted/spread, etc. We envision bioluminescent circRNA as a powerful tool that can be applied in all fields: from environmental monitoring to agricultural improvement.
Under those right conditions, circRNA lights up — or more accurately puts out luminscence, as in the case of oneselowered by luciferin. This circRNA is thought to help control what goes on in the genes and other functions of cells inside whatever lives and glows. Image via BiRD Lab @ UTSW The more interactions we know about, the more fuel for creative potential can be used to spark this new fire of bioluminescent circRNA in different domains.
Bioluminescent circRNA and Application Prospects in Genetic Research. CircRNA is more stable than straight RNA due to its circular feature. The Gluc-PAmCherry was stable, which meant that it could be a good tool for gene therapy — a type of treatment where genes are altered to prevent or treat disease. In addition, the bioluminescent circRNA can be used by scientists to trace cell movement in their studies. Being able to watch cell movement they can get a clearer insight into how diseases spread and the effectiveness of some forms of treatment. As time goes on, I suspect that we will use bioluminescent circRNA to treat disease states that were previously untouchable.
Yaohai Bio-Pharma, a Bioluminescent circRNA manufacturer of biological products, is a specialist in microbial fermentations. We have built a modern factory equipped with modern facilities and strong RD and manufacturing capabilities. Five drug substance production lines that are compliant with GMP standards for microbial purification and ferment, as well as two fill and finish lines for vials as well as cartridges, as well as needles that are pre-filled, are readily available. The available fermentation scales vary from 100L to 500L, 1000L, to 2000L. Filling volumes vary from 1ml to 25ml. Syringes or cartridges pre-filled are filled with the equivalent of 1-3ml. Our cGMP-compliant production facility ensures the availability of stable clinical samples and commercial products. The big molecules that are produced at our plant are readily available for international delivery.
Yaohai Bio-Pharma is Bioluminescent circRNA in microbial-derived biologics. We offer custom RD as well as manufacturing solutions, while minimising the risk. We've been involved in numerous modalities like recombinant subunit vaccines, peptides hormones, cytokines growth factors, single-domain antibodies, enzymes, plasmid DNA, the mRNA, and other. We are experts in several Microbial hosts, such as yeast extracellular and intracellular (yield up to 15 grams per liter) bacteria periplasmic secretion as well as soluble intracellular inclusion bodies (yield up to 10 grams/L). Additionally, we have developed the BSL-2 microbial fermentation platform for the development of bacterial vaccines. We have a track record of improving production processes, thereby increasing yields, and reducing costs. With a highly efficient technology team, we guarantee prompt and reliable project delivery and bring your products to market quicker.
Yaohai Bio-Pharma is a leading in Bioluminescent circRNA CDMO. Our main focus has been the production of microbial vaccinations and therapeutics to treat pets, human and veterinary health. We possess cutting-edge RD and manufacturing technology platforms that cover the entire manufacturing process from the engineering of microbial strains, to cell banking processing and method design to clinical and commercial manufacturing, making sure that we can ensure the successful delivery of the most advanced solutions. We have accumulated a huge quantity of knowledge in the bio processing microbial field. More than 200 projects have been successfully completed and we help our clients comply with regulations like those of the US FDA as well as EU EMA. We also help them to navigate Australia TGA and China NMPA. We are able to respond rapidly to market requirements and offer customized CDMO services due to our experience and expertise.
Yaohai BioPharma, a Bioluminescent circRNA Microbial CDMO, integrates regulatory affairs and quality management. We have a quality system that is compliant with current GMP standards, as well as regulations around the globe. Our regulatory team is knowledgeable in global regulatory frameworks to expedite biological launches. We make sure that production processes are traceable, high-quality products, and complying with the rules of the US FDA and EU EMA. Australia TGA and China NMPA is also fulfilled. Yaohai BioPharma has successfully passed the audit on site of the European Union's Qualified Person (QP) to ensure our GMP quality system and production site. We also have passed the initial certification audits of the ISO9001 Quality Management System and ISO14001 Environmental Management System.