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Interferon-γ (INF-γ)

Interferon-γ (INF-γ)

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Modality

Interferon-γ (INF-γ)

Interferons (INFs) are cytokines secreted at the beginning of viral infection that have both antiviral and antiproliferative effects. As a class of human INFs, human recombinant interferon gamma (INF-γ) has been approved to treat chronic granulomatous disease and osteoporosis and is increasingly likely to be used as a cancer immunotherapy.

As they do not require posttranslational manipulations to display biological activity, the recombinant INFs currently produced in Escherichia coli (E. coli) is in clinical practice.

Application of Interferon-γ (INF-γ)

Being an interferon gamma, Actimmune (Interferon gamma-1b) is a single-chain polypeptide with 140 amino acids, which is produced by fermentation in genetically engineered E. coli bacterium that contains recombinant protein-coding DNA. The product is purified by conventional column chromatography and developed by Horizon Pharma.

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INF-γ Pipelines

Generic name

Brand Name/

Alternative name

Expression System

Indications

Manufacturer

Latest stage

Recombinant human interferon γ-1b

Actimmune, Interferon gamma-1b,

IFN-gamma-1b, Interferon gamma 1-b, Interferon gamma-1b, recombinant

Interferon gamma-2a

Escherichia coli (E. coli)

Infection

Horizon Pharma

Approval

Injection - Recombinant human interferon γ

Gamma,伽玛

E. coli

Rheumatoid arthritis; Liver fibrosis; Chronic granulomatous disease

Chemowanbang Biopharma

Approval

Interferon alpha-2b/interferon gamma

Interferon-gamma/interferon-alpha-2b, CIGB-128, CIGB-128-A

Pending update

Tumor, Infectious diseases

Heber Biotec SA

Phase II

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