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Interferon-α (INF-α)

Interferon-α (INF-α)

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Modality

Interferon-α (INF-α)

Interferons (INFs) are cytokines secreted during the early stages of viral infection that have antiviral and antiproliferative effects. Three types of INFs are present in the human body: INF-α, INF-β, and INF-γ. The INF-α subtypes is the most widely used INF for therapeutic purposes.

Recombinant INF-α and PEG-conjugated INF-α are currently approved for curing patients suffered from viral infections and cancers, such as hepatitis B, hepatitis C, and malignant melanoma.

Recombinant INF-α is typically produced in Escherichia coli (E. coli) and is currently used in clinical practice because it does not require post-translational modification to exhibit biological activity.

Application of Interferon-α (INF-α)
Interferon alfa-2a (INF-α-2a)

Interferon alpha-2a, the active substance of Roferon-A, is a highly purified protein with a molecular weight of approximately 19 kDa and contains 165 amino acids. Developed by Roche and manufactured using recombinant DNA technology, roferon-A applies a genetically engineered Escherichia coli containing DNA that codes for the human protein.

Peginterferon alfa-2a

Pegasys (peginterferon alfa-2a) is a covalent linker consisting of recombinant interferon alfa-2a (approximately 20 kDa) and branched bis-monomethoxy polyethylene glycol (PEG) chains (approximately 40 kDa). Through a stable amide bond to lysine, the PEG moiety binds to the interferon alfa moiety at a single site. Interferon-alpha-2a is manufactured by recombinant DNA technology in which the cloned human leukocyte interferon gene is inserted into and expressed in E. coli. The Pegasys formulation was developed by Roche/Genentech and acquired by zr pharma worldwide (except China and Japan).

Interferon alfa-2b

Produced by recombinant DNA technology, Intron-A (interferon-alpha-2b) is a purified, sterile recombinant alpha interferon product, which is produced by bacterial fermentation of E. coli strain carrying a genetically engineered plasmid that contains the interferon alfa-2b gene extracted from human leukocytes. And intron A was developed by Schering-Plough and Merck Sharp & Dohme.

Peginterferon alfa-2b

Pegintron (peginterferon α-2b) is a covalent bond consisting of recombinant interferon α-2b and monomethoxy polyethylene glycol (PEG). With a molecular weight of 19 kDa, Interferon α-2b is a water-soluble protein and developed by recombinant DNA techniques. Developed by Schering-Plough and Merck Sharp & Dohme, it is produced by bacterial fermentation of an E. coli strain carrying a recombinant plasmid containing the human leukocyte interferon gene.

Interferon for Animal Use

Feline Interferon

Yaohai Bio-Pharma Offers One-Stop CDMO Solution for INF-α
INF-α Pipelines

Generic name

Brand Name/

Alternative name

Expression System

Indications

Manufacturer

Latest stage

Recombinant human interferon α-2b-INTRON A

YM-14090, Viraferon, IntronA, Intron A,甘乐能

Escherichia coli (E. coli)

Tumor, Infectious diseases, Digestive system diseases, blood system diseases

MSD, Merck, schering plough

Approval

Pegylated Interferon α-2b

PegIntron,佩乐能, Redipen, Peg-Intron, Virtron, C-Pegferon, Cylatron

E. coli

Tumor, Infectious diseases, Digestive system diseases, blood system diseases

MSD, Merck, schering plough

Approval

Recombinant human interferon α-2a

ROFERON-A

E. coli

Tumor, Infectious diseases, blood system diseases, Digestive system diseases

Roche

Approval

Polyethylene glycol recombinant interferon α-2a

派罗欣, Pegasys,ペガシス

E. coli

Infectious diseases, Digestive system diseases, Immune system diseases, Tumor, blood system diseases, Urinary system diseases

Nektar Therapeutics, Roche, Aradigm, InterMune, Chugai Pharmaceutical Co., Ltd.

Approval

interferonα-1

Interferon alfacon-1, YM 643, IFN-Con1, Inferax, Advaferon, Infergen

E. coli

Tumor, Infectious diseases

Amgen, Astellas Pharma Inc, Takeda, Kadmon Pharmaceuticals, Chiesi Pharmaceutical (Shangai) Co., Ltd

Approval

Proline interferon α-2b

Ropeginterferon alfa-2b-njft, P-1101, AOP-2014, Besremi,ベスレミ

E. coli

Infectious diseases, Tumor, blood system diseases, Digestive system diseases

PharmaEssentia, AOP Orphan

Approval

Recombinant human interferon α2b (Pseudomonas)

里亚美,利分能

Pseudomonas

Tumor, Infectious diseases

HAPHARM GROUP CO.,LTD.

Approval

Recombinant interferon α-2a

Interferon α-2a-Inmutag, Inferon, Inmutag, Inter 2A

Pending update

Tumor, Infectious diseases

Biosidus

Approval

Recombinant interferon α-2b

peginterferon alfa-2b-Bioferon, Citopheron, Ganapar, Zavinex, Inter 2B

Pending update

Tumor, Infectious diseases

Biosidus

Approval

Polyethylene glycol recombinant interferon α-2b

peginterferon alfa-2b

Pending update

Tumor, Infectious diseases

Biocad

Approval

Interferon α-2b

Pending update

Pending update

Tumor, Infectious diseases

BioGeneric Pharma SAE

Approval

interferon α-2a

INTEFEN-IFN

Pending update

Tumor, Infectious diseases

Biolotus Biotech Ltda

Approval

interferon α-2a

BLAUFERON-A

Pending update

Tumor, Infectious diseases

Blau Farmacêutica SA

Approval

interferon-α2

Pending update

Pending update

Tumor, Infectious diseases

CJ CheilJedang Corp.

Approval

interferon α-2a biosimilars

r-hu-IFNa2

Pending update

Tumor, Infectious diseases

Elea Spa

Approval

interferon α-2b

Pending update

Pending update

Tumor, Infectious diseases

Fundação Oswaldo Cruz

Approval

interferon α-2b

Pending update

Pending update

Tumor, Infectious diseases

Getz Pharma Research

Approval

Interferon α-2a

迪恩安

Pending update

Tumor, Infectious diseases

Liaoning Satellite

Approval

Pegylated interferon α2a

Optipeg-A

Pending update

Tumor, Infectious diseases

Incepta Pharmaceuticals Ltd.

Approval

interferonα-2b

Pending update

Pending update

Tumor, Infectious diseases

Intas Biopharmaceuticals

Approval

Pegylated Interferon α-2b

Pending update

Pending update

Tumor, Infectious diseases

Intas Biopharmaceuticals

Approval

interferonα-2b

Heberon Alfa R, Inrec

Pending update

Tumor, Infectious diseases

International Centre for Genetic Engineering and Biotechnology

Approval

interferonα-2b

Pending update

Pending update

Tumor, Infectious diseases

Keepharma Ltd.

Approval

interferon α-2b

Pending update

Pending update

Tumor, Infectious diseases

Laboratorio Varifarma SA

Approval

interferon α-2b

Lanstion

Pending update

Tumor, Infectious diseases

Landsteiner Scientific SA de CV

Approval

Pegylated Interferon α-2b biosimilars

Pegstat

Pending update

Tumor, Infectious diseases

Nanogen Pharmaceutical

Approval

interferon α

OPC-18, IFN-alpha, Alfaferone, Oif

Pending update

Tumor, Infectious diseases

Otsuka Holdings Co., Ltd.

Approval

Recombinant human interferon α

Interferon Alfa

Pending update

Tumor, Infectious diseases

Reliance Life Sciences

Approval

interferon α-2b

ReliFeron

Pending update

Tumor, Infectious diseases

Reliance Life Sciences

Approval

interferon α-2a

Reiferon

Pending update

Tumor, Infectious diseases

Rhein-Minapharm

Approval

interferon α-2b

Kalferon

Pending update

Tumor, Infectious diseases

PT Kalbe Farma Tbk

Approval

interferon α-N3

interferon alfa-N3

NA, extract from leucocytes

Tumor, Infectious diseases

Stem Cell Innovations

Approval

interferon α-2b

Pending update

Pending update

Tumor, Infectious diseases

Teva Pharmaceutical Industries Ltd

Approval

Pegylated interferon α2a

Pegaferon

Pending update

Tumor, Infectious diseases

Panpharmaceuticals

Approval

Pegylated Interferon α-2b

Pending update

Pending update

Tumor, Infectious diseases

Panpharmaceuticals

Approval

interferon α-2b

Altevir

Pending update

Tumor, Infectious diseases

Pharmapark LLC

Approval

interferon α-2b

Pending update

Pending update

Tumor, Infectious diseases

PharmBiotek Research and Production LLC

Approval

interferon α-2b

Alfarona, Alpharona, Alfaron

Pending update

Tumor, Infectious diseases

Pharmaclon

Approval

interferon α-2a

Pending update

Pending update

Tumor, Infectious diseases

Pooyesh Darou Biopharmaceuticals

Approval

interferon α-2b

PDferon-B

Pending update

Tumor, Infectious diseases

Pooyesh Darou Biopharmaceuticals

Approval

interferon α-2b

Urifron

Pending update

Tumor, Infectious diseases

Probiomed SA de CV

Approval

interferon α

Leu-IFN, Multiferon

Pending update

Tumor, Infectious diseases

Viragen, Inc.

Approval

interferon α-2b

VIPEG

Pending update

Tumor, Infectious diseases

Virchow Group

Approval

interferon α-2b

Reaferon-EU-Lipint, Reaferon-EC-Lipint, Reaferon-ES-Lipint

Pending update

Tumor, Infectious diseases

Vektor Medika

Approval

interferon α-2b

Pending update

Pending update

Tumor, Infectious diseases

Zydus Lifesciences Ltd.

Approval

Pegylated Interferon α-2b

Pending update

Pending update

Tumor, Infectious diseases

Zydus Lifesciences Ltd.

Approval

interferon α-2b

Intermax Alpha

Pending update

Tumor, Infectious diseases

LG Chem

Approval

interferon α-2b

rHuIFNa-2b,安达芬

Pending update

Tumor, Infectious diseases

Anhui Anke Biotechnology (Group) Co., Ltd

Approval

Recombinant human interferon α-2b

interferon alpha 2b,凯因益生

Pending update

Tumor, Infectious diseases

Beijing Kawin Technology Share-Holding Co., Ltd.

Approval

CePEG-IFN

Cepeginterferon alfa-2b, Algeron, Pegylated human interferon A-2B, CePEG-IFN

Pending update

Tumor, Infectious diseases

Biocad

Approval

interferon α

Interferon alpha vaginal, Interferon alpha vaginal, Opin

Pending update

Tumor, Infectious diseases

Vitapharm Technology

Approval

Recombinant human interferon α2b

Pending update

Pending update

Tumor, Infectious diseases

Yuance

Approval

Recombinant human interferon α2a gel

Recombinant interferon alpha-2a,忆林, Yilin

Pending update

Tumor, Infectious diseases

Changchun ChangSheng Gene Pharmaceutical Co., Ltd

Approval

Recombinant human interferon α2b

长生扶康

Pending update

Tumor, Infectious diseases

Changchun institute of biological products

Approval

interferonα-2a

Pending update

Pending update

Tumor, Infectious diseases

Changchun institute of biological products

Approval

Recombinant human interferon α

Interferon Alfa

Pending update

Tumor, Infectious diseases

Sumitomo Pharma

Approval

Recombinant human interferon α2b

尤尼隆

Pending update

Tumor, Infectious diseases

Hainan Unipul Pharmaceutical Co., Ltd

Approval

interferonα-2a

贝尔芬

Pending update

Tumor, Infectious diseases

Hainan Xinmingda Bio-Pharma

Approval

interferonα-2b

Pending update

Pending update

Tumor, Infectious diseases

Furuibang Group

Approval

Recombinant human interferon α2b

尤靖安

Pending update

Tumor, Infectious diseases

Lee's Pharmaceutical

Approval

Recombinant human interferon α-2a

Interferon alfa 2a

Pending update

Tumor, Infectious diseases

3SBIO

Approval

Y type Polyethylene glycol recombinant interferon α-2b

派格宾

Pending update

Tumor, Infectious diseases

Amoytop

Approval

Recombinant human interferon α2b

万复因

Pending update

Tumor, Infectious diseases

Tenry

Approval

Recombinant human interferon α2a

万复洛

Pending update

Tumor, Infectious diseases

Tenry

Approval

Recombinant human interferon α2b

辛复宁,辛化诺

Pending update

Tumor, Infectious diseases

Shanghai Huaxin Biotechnology Co., Ltd

Approval

Recombinant human interferon α-2b

interferon alpha 2b

Pending update

Tumor, Infectious diseases

Shanghai Wanxing

Approval

Recombinant human interferon α-2a

Interferon alfa 2a

Pending update

Tumor, Infectious diseases

Shanghai Wanxing, Tenry

Approval

Recombinant human interferon α-2b

Recombinant human interferon alpha-2b

Pending update

Tumor, Infectious diseases

Interlong

Approval

Recombinant human interferon α-2b

安福隆,捷抚

Pending update

Tumor, Infectious diseases

SINOBIOWAY Medicine

Approval

interferon α-2b

rHuIFNa-2b

Pending update

Tumor, Infectious diseases

Changchun Heberbiological Technology Co., Ltd

Approval

interferon α-2a

因特芬

Pending update

Tumor, Infectious diseases

3SBIO

Approval

Recombinant human interferon α2b

莱福隆

Pending update

Tumor, Infectious diseases

Beisheng Pharma Hansheng

Approval

Recombinant human interferon α2a

奥平

Pending update

Tumor, Infectious diseases

Wuhan weiao

Approval

Y type Polyethylene glycol recombinant interferon α-2a

Y shaped pegylation interferon α-2a

Pending update

Tumor, Infectious diseases

Amoytop

Phase II/III

Polyethylene glycol recombinant interferon α

Peginterferon alpha

Pending update

Tumor, Infectious diseases

European Organisation for Research and Treatment of Cancer

Phase III

Interferon alpha-2b/interferon gamma

Interferon-gamma/interferon-alpha-2b, CIGB-128, CIGB-128-A

Pending update

Tumor, Infectious diseases

Heber Biotec SA

Phase II

Recombinant human interferon α-2b inhalant -AP003

interferon alpha 2b inhalation-AP003, AntiCovir, AP 003

Pending update

Tumor, Infectious diseases

Altum Pharmaceuticals, BetterLife Pharma

Phase II

Recombinant human interferon α

Interferon Alfa

Pending update

Tumor, Infectious diseases

Amarillo Biosciences

Phase II

Pegylated interferon alpha-2a

PegIFN-alpha2a

Pending update

Tumor, Infectious diseases

Janssen Research & Development LLC

Phase II

IFNα-Kinoid

Human IFN-α2b coupled to a T-helper carrier protein, CKD971, SS-002, SS002, SS 002

Pending update

Tumor, Infectious diseases

Centurion Pharma, Chong Kun Dang, Neovacs, Biosense Global

Phase II

interferonα1b

Peginterferon α1b

Pending update

Tumor, Infectious diseases

Shanghai Institute of Biological Products Co., Ltd

Phase II

interferonα-N1

Interferon alpha-N1

Pending update

Tumor, Infectious diseases

GSK

Phase II

Polyethylene glycol recombinant interferon α-2b

peginterferon alfa-2b

Pending update

Tumor, Infectious diseases

Anhui Anke Biotechnology (Group) Co., Ltd

Phase II

interferonα-2b

Hanferon, HL-031

Pending update

Tumor, Infectious diseases

Nautilus Biotech

Phase II

Recombinant human interferon α-2b喷雾剂

Pending update

Pending update

Tumor, Infectious diseases

Anhui Anke Biotechnology (Group) Co., Ltd

Phase II

Recombinant human interferon α-2b

interferon alpha 2b

Pending update

Tumor, Infectious diseases

Hanall

Phase I/II

MSC-IFN α

Pending update

Pending update

Tumor, Infectious diseases

Wuxi Huatai Innovative Pharmaceutical

Phase I/II

SAR441000

an mRNA mixture encoding IL-12sc, interferon alpha2b, GM-CSF and IL-15

Pending update

Tumor, Infectious diseases

Sanofi, BioNTech

Phase I

Recombinant human serum albumin and interferon α-2b fusion protein

Recombinant human serum albumin and interferon α-2b-kangbao group

Pending update

Tumor, Infectious diseases

Shanxi Kangbao

Phase I

Recombinant human interferon α-2b

interferon alpha 2b

Pending update

Tumor, Infectious diseases

Kexing Biopharma

Phase I

Recombinant human serum albumin interferon α2a fusion protein

Pending update

Pending update

Tumor, Infectious diseases

Qilu Pharmaceutical

Phase I

Recombinant human serum albumin interferon α2a fusion protein

rHSA-IFN alpha-2a, SFR-9213

Pending update

Tumor, Infectious diseases

Fortunerock (China)

Phase I

Recombinant human serum albumin and interferon α-2b fusion protein

Recombinant human serum albumin and interferon α-2b-kangbao group

Pending update

Tumor, Infectious diseases

Anhui Anke Biotechnology (Group) Co., Ltd

Pre-clinical

Polyethylene glycol recombinant interferon α-2b

peginterferon alfa-2b

Pending update

Tumor, Infectious diseases

SL Pharm

Pre-clinical

AL-683

Hyperglycosylated IFN Alfacon-1

Pending update

Tumor, Infectious diseases

Alios BioPharma

Pre-clinical

AL-624

Hyperglycosylated IFN Alfacon-1

Pending update

Tumor, Infectious diseases

Johnson Johnson, Alios BioPharma

Pre-clinical

Polyethylene glycol recombinant interferon α-2b

peginterferon alfa-2b

Pending update

Tumor, Infectious diseases

Shanghai Meiye Biotechnology

Pre-clinical

Recombinant human interferon α

Interferon Alfa

Pending update

Tumor, Infectious diseases

Shanghai GeneCore BioTechnologies

Pre-clinical

Recombinant human serum albumin and interferon α-2b fusion protein

Recombinant human serum albumin and interferon α-2b-kangbao group

Pending update

Tumor, Infectious diseases

Wolwo Pharma

Pre-clinical

Recombinant human interferon α-2a-Tumor vascular specific binding peptidesNGR fusion protein

Pending update

Pending update

Tumor, Infectious diseases

JIUZHOU Group

Pre-clinical

Recombinant human interferon α-2b喷雾剂

Pending update

Pending update

Tumor, Infectious diseases

Amoytop

Pre-clinical

Recombinant human interferon α

Interferon Alfa

Pending update

Tumor, Infectious diseases

Ainos, Inc.

Pre-clinical

Q101 type Polyethylene glycol recombinant interferon α-2a

Q101 pegylation interferon α-2a, PEG-IFN-α-2a, Q-101

Pending update

Tumor, Infectious diseases

CSPC Pharma

Pending update

Pegylated Interferon α-2b

Pending update

Pending update

Tumor, Infectious diseases

Pharmstandard PJSC

Pending update

Polyethylene glycol recombinant interferon α-2a

Peginterferon Alfa-2a

Pending update

Tumor, Infectious diseases

CHITAI TIANQING

Pending update

Polyethylene glycol recombinant interferon α-2b

peginterferon alfa-2b

Pending update

Tumor, Infectious diseases

Changchun Heberbiological Technology Co., Ltd

Pending update

Q101 type Polyethylene glycol recombinant interferon α-2a

Q101 pegylation interferon α-2a, PEG-IFN-α-2a, Q-101

Pending update

Tumor, Infectious diseases

CSPC Pharma

Pending update

Polyethylene glycol recombinant interferon α-2b

peginterferon alfa-2b

Pending update

Tumor, Infectious diseases

Amoytop

Pending update

Albumin interferon α

Albumin-Interferon Alfa, alb-IFN, Albinterferon

Pending update

Tumor, Infectious diseases

GSK, Novartis, Human Genome Sciences

Pending update

Recombinant human serum albumin and interferon α-2b fusion protein

Recombinant human serum albumin and interferon α-2b-kangbao group

Pending update

Tumor, Infectious diseases

Hangzhou Jiuyuan Gene Engineering Co., Ltd

Pending update

interferonα-2b

Pending update

Pending update

Tumor, Infectious diseases

AXXO Im- und Export GmbH

Pending update

Recombinant human interferon α-2a

Interferon alfa 2a

Pending update

Tumor, Infectious diseases

BioPartners GmbH

Pending update

interferonα-2b

AP-001

Pending update

Tumor, Infectious diseases

Helix BioPharma Corp.

Pending update

recombinant consensus interferon α

Recombinant consensus interferon α

Pending update

Tumor, Infectious diseases

SL Pharm

Pending update

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