Description of Gardasil 9
Gardasil 9 is a recombinant human papillomavirus (HPV) vaccine against 9 types of HPV, i.e., types 6, 11, 16, 18, 31, 33, 45, 52, and 58. The active ingredient in Gardasil 9 is purified virus-like particles (VLPs) of the major capsid (L1) protein of the 9 types of HPV. Gardasil 9 contains aluminum-based adjuvant. Gardasil 9 was developed by Merck Sharp & Dohme and was available in 2014.
Synonyms
V503, Gardasil 9, Silgard 9, 佳达修 9,シルガード 9.
Formulation of Gardasil 9
|
Active ingredients in Gardasil 9
HPV 6 L1 protein, HPV 11 L1 protein, HPV 16 L1 protein, HPV 18 L1 protein, HPV 31 L1 protein, HPV 33 L1 protein, HPV 45 L1 protein, HPV 52 L1 protein, HPV 58 L1 protein expressed in yeast Saccharomyces cerevisiae
|
|
Inactive ingredients in Gardasil 9
Aluminum hydroxyphosphate sulfate (adjuvant), sodium chloride, L-histidine, plysorbate 80, sodium borate, and water for injection.
|
Expression system of HPV L1 Protein
Yeast (Saccharomyces cerevisiae)
Manufacturing Process of HPV L1 Protein
Drug Substance Manufacturing
- Yeast fermentation to produce self-assembled VLPs
- Yeast cell disruption to release HPV L1 VLPs
- VLP purification
Drug Product Manufacturing
- Combining each type of VLP with aluminum-based adjuvant
- Formulation preparation and sterilizing filtration
- Aseptic fill-finish
Yaohai Bio-Pharma Offers One-Stop CDMO Solution for HPV Vaccine
EN
AR
HR
CS
DA
NL
FI
FR
DE
EL
IT
JA
KO
NO
PL
PT
RO
RU
ES
SV
IW
ID
LV
LT
SR
SK
SL
UK
VI
ET
HU
TH
TR
FA
AF
MS
BE
MK
UR
BN
