Protein stability is dominant when it comes to studying the vitro protein and the functions of folded and recombinant proteins. As such, it is crucial to fully understand protein stability and preserve the folded conformation and normal functions of proteins of interest. As the “gold standard” for protein thermal stability analysis, Differential Scanning Calorimetry (DSC) outputs precise and high-quality data. Thus, it provides vital information on protein stability in process development, and the formulation of potential therapeutic candidates.
Yaohai Bio-Pharma offers Thermal Stability Analysis Services based on the DSC method.
We have been involved in the Protein Structural Characterization of various large molecules, including Recombinant Subunit Vaccines, Nanobodies/ Single-domain Antibodies (sdAbs), Antibody Fragments, Hormones/Peptides, Cytokines, Growth Factors (GF), Enzymes, Collagens, etc.
Analytical Methods
| Analysis |
Methods |
| Thermal Stability (Tm) |
Differential Scanning Calorimetry (DSC) |
Analytical Procedures
1. Sample preparation;
2. Buffer-buffer scans to obtain an accurate baseline;
3. Protein sample scans to obtain DSC scanning curves;
4. Data analysis to obtain transition temperatures (Tm), calorimetric enthalpy (ΔH) and other thermodynamic parameters.
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