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Explore the Fascinating World of the Lithium Chloride Precipitation

Oct 28, 2024

Lithium chloride precipitation is widely used for separating RNA from solution. Here's the breakdown of the process: 1. Sample preparation: Start with a sample containing RNA, such as in-vitro transcript mixture. 2. Lithium chloride addition: Add an...

Recombinant Protein Production: Engineered E. coli Strains
Oct 25, 2024
Escherichia coli (E. coli) has played a significant role in producing recombinant proteins in the biopharmaceutical industry, serving as the first expression vector for manufacturing biological medicine. E. coli boasts rapid growth, convenient geneti...
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2024 Updated mRNA Purification Methods
Oct 23, 2024
Purification, a crucial step in mRNA production, involves removing impurities such as unreacted chemicals or residual materials. The purification process ensures batch-to-batch consistency of mRNA and lipid nanoparticle (LNP) formulations, removing u...
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The Magic of P. pastoris: Shaping Recombinant Protein Production
Oct 16, 2024
Recombinant proteins, which are proteins expressed in host cells through genetic engineering techniques, have found widespread applications in biomedical research, therapy, and diagnostics. The selection of an appropriate expression system is a cruci...
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DNA Vaccine Production Scale-up Strategies
Oct 14, 2024
Since the initial demonstration of gene expression in vivo through naked DNA injection, DNA vaccines, and gene therapies have advanced significantly. Plasmid DNA is used in both approaches to treat diseases by inducing protein expression. In comparis...
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Nanobodies Meet CAR-T: Shaping the Future of Cancer Therapy
Oct 10, 2024
Chimeric Antigen Receptor T-cell (CAR-T) therapy is an emerging cellular immunotherapy that genetically modifies T-cells to express Chimeric Antigen Receptors (CARs) on their surfaces. These receptors enable T-cells to recognize and specifically targ...
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The Manufacturing Process and Applications of Nanobody
Oct 09, 2024
By targeting specific viruses or structures, engineered antibodies can potentially treat certain high-risk populations. However, similar to monoclonal antibodies, their widespread application is hindered by the high production costs and their large s...
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Plasmid DNA: The Key to Unlocking Cancer's Therapy Code
Sep 27, 2024
Recently, gene therapy has showcased the huge potential in cancer treatment. It can introduce exogenous normal genes into human target cells to repair, replace, or modulate genes within the patient, ultimately achieving therapeutic goals at the ...
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Polypeptides Drugs: The Future of Biomedicine
Sep 26, 2024
The market for polypeptide drugs is experiencing rapid growth in the biomedical sector, with an annual compound growth rate of 8.5% globally from 2020 to 2030, expected to reach US$141.8 billion by 2030. Polypeptide drugs are produced via methods lik...
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Yeast: Key Player in VLP Vaccine for Polio
Sep 25, 2024
Poliomyelitis (polio) is caused by a virus, with symptoms including fever, upper respiratory discomfort, and limb paralysis. The disease is preventable but difficult to cure, and can easily lead to lifelong disability or even death. Thus, vaccines ar...
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Marvelous Fermentation Rate Control Strategies
Sep 24, 2024
Microbial fermentation rate control aims to optimize growth conditions by precisely adjusting key factors such as temperature, pH, dissolved oxygen, and substrate concentration, ensuring that microorganisms are in their optimal physiological state. T...
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Pet's Dedicated Insulin Solution for a Sweet Life
Sep 23, 2024
Diabetes mellitus (DM) is a prevalent disease that affects not only humans but also our beloved pets. As pets' diets improve, their chances of developing diabetes increase due to higher rates of obesity. Based on the database encompassing 2.5 million...
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Harnessing the Power of Fed-batch Fermentation Strategy
Sep 20, 2024
Pichia pastoris is widely used in the production of various heterologous proteins. The High-Cell-Density Fermentation (HCDF) technology, implemented through Fed-Batch feeding, has successfully achieved large-scale production of biopharmaceuticals and...
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Conquering Hepatitis B with Yaohai
Sep 19, 2024
The World Health Organization (WHO) reports that annually, 1.5 million new cases of chronic hepatitis B infection emerge, affecting 296 million individuals globally. Hepatitis B is the disease that causes the most deaths after COVID-19. Therefore, we...
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Comparative Analysis of Yeast and E. coli in Release Testing
Sep 18, 2024
In the field of biopharmaceuticals, Escherichia coli (E. coli) and yeast are two widely used microbial expression systems that have addressed significant challenges such as industrialization and batch-to-batch stability of biological products. Levera...
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Do You Know the Groundbreaking Advancement in Insulin Technology?
Sep 14, 2024
Recombinant human insulin is a paradigmatic case of the mass production of genetically engineered drugs and a crucial application for microbial expression. Since its discovery a century ago, insulin medications have undergone continuous advancements,...
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The Application of VLPs in Human and Veterinary Vaccines
Sep 13, 2024
Last week, we briefly introduced the features, mechanisms of action (MoA), and expression systems of VLPs (Virus-like Particles). VLPs are viral structural proteins that do not contain viral genetic material. Besides, their advantages include nanosca...
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VLPs and Its Manufacturing Process
Sep 12, 2024
Virus-like Particles (VLPs) are unique biomaterials that have similar structures to viruses but essentially do not contain viral genetic material such as DNA or RNA. Therefore, VLPs wouldn't lead to infections in the human body. Due to this character...
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Methods to Improve the Yield of pDNA
Sep 11, 2024
The production of plasmid DNA (pDNA) relies on genetic recombination, which involves connecting the target gene and other elements to form a covalently closed circular structure. High cell-density fermentation of Escherichia coli and purification are...
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Congratulations to Yaohai’s CDMO Client
Aug 15, 2024
Good news! Northland Biotech's Naked Plasmid NL003 BLA was accepted by NMPA On July 16 2024, the valued client of Yaohai Bio-Pharma, Beijing Northland Biotechnology Co., Ltd. (Northland), announced that its independently developed Category 1 new th...
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