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Breakthrough Drug pUDK HGF: Light for Lower Limb Ischemia Patients

Dec 06, 2024

Good news! Humanwell Healthcare and Yaohai Bio-Pharma jointly submitted a BLA for pUDK HGF On December 4th, according to the CDE website, Humanwell Healthcare and Yaohai Bio-Pharma jointly submitted a biologics license application (BLA) for pUDK hepa...

Nanobodies: The Arising Star in Breast Cancer Treatment
Dec 05, 2024
Nanobodies exhibit unique advantages in breast cancer treatment due to their small size, high stability, and low immunogenicity. They can rapidly penetrate tumor tissues and effectively exert their therapeutic effects, while also being relatively low...
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Innovative Assembly Techniques for Large-Scale Gene Synthesis
Dec 04, 2024
The assembly technology for synthesizing large DNA fragments from scratch is the cornerstone of gene synthesis, encompassing methods such as BioBrick™, TAR, BglBrick, Golden Gate, Gibson assembly, CPEC, and Overlap PCR. Due to the limitations o...
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Selective Modifications for eGFP Reporter mRNA
Dec 03, 2024
When enhancing the performance of eGFP reporter mRNA, choosing the right nucleotide modifications is crucial. A strategic approach involves considering both the biological context and the specific experimental goals. The cell type and environment&nbs...
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Harnessing the power of VLPs for Allergy Treatment
Dec 02, 2024
Allergy is a prevalent disease, and VLPs in immune engineering offer new treatment options. VLPs, made of viral capsids without genetic material, are highly immunogenic, modulate immunity efficiently, and are low in allergenicity. For food allergies,...
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Enhancing eGFP Reporter mRNA with Nucleotide Modifications
Nov 28, 2024
In the advancing frontier of synthetic biology, nucleotide modifications have emerged as a powerful tool to enhance the performance of reporter mRNAs, such as those encoding enhanced green fluorescent protein (eGFP). These modifications not only impr...
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Why Use eGFP Reporter mRNA as a Control?
Nov 27, 2024
In the realm of molecular biology and gene expression studies, enhanced green fluorescent protein (eGFP) reporter mRNA has become a cornerstone for experimental controls. Its utilization stems from several compelling reasons. Firstly, fluorescent mar...
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VLPs: Pioneering Prevention in Infectious Diseases & Cancer
Nov 26, 2024
Virus-like Particles (VLPs) bridge nanotechnology, immunology, and synthetic biology, pivotal in preventing and treating infectious diseases and cancer. With years of CDMO experience, Yaohai Bio-Pharma excels in recombinant protein vaccine developmen...
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Pros and Cons of eGFP Reporter mRNA
Nov 25, 2024
Enhanced green fluorescent protein (eGFP) reporter mRNA has emerged as a powerful tool in biological research due to its distinct advantages. However, like any other technology, it also has limitations. Advantages: High Sensitivity and Ease of Detect...
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Unveiling the Optimal Dosage of eGFP Reporter RNA
Nov 22, 2024
In molecular biology and biotechnology, enhanced green fluorescent protein (eGFP) has emerged as a pivotal reporter gene due to its ability to produce bright green fluorescence at 509 nm. This protein, originally isolated from the jellyfish Aequorea ...
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Manufacturing Process of eGFP mRNA
Nov 21, 2024
The production of eGFP (Enhanced Green Fluorescent Protein) mRNA involves a series of molecular biology techniques to generate a functional RNA molecule that encodes for the expression of the eGFP. In the area of eGFP mRNA, Yaohai Bio-Pharma has accu...
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International Summit on Cross-Innovation and High-Quality Development of Nanobodies: Conversations with Serge Muyldermans
Nov 19, 2024
From November 16th to 17th, 2024, the First International Summit on Cross-Innovation and High-Quality Development of Nanobodies was held in Nanning, Guangxi, China. This academic event brought together experts and scholars from around the world to di...
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Unlocking the Glow: eGFP as the Star of Reporter RNAs
Nov 18, 2024
Enhanced Green Fluorescent Protein (eGFP), a genetically engineered variant of the naturally occurring Green Fluorescent Protein (GFP), has revolutionized how researchers visualize and track gene expression, protein localization, and cellular interac...
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Nanobody: The Breakthrough on Thrombosis Treatment
Nov 15, 2024
Introduction Factor XII (FXII), a key player in blood coagulation and inflammation, has emerged as a promising therapeutic target. Researchers have developed a nanoantibody (Nb) targeting FXII with high affinity and neutralizing activity. Anti-thromb...
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The Versatile Role of eGFP Reporter RNA
Nov 13, 2024
In the intricate world of molecular biology, fluorescent proteins have emerged as invaluable tools, enabling researchers to visualize and track cellular processes in real-time. Among these, Enhanced Green Fluorescent Protein (eGFP) stands out as a be...
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Gene Therapy Evolution: Novel DNA & Optimization
Nov 12, 2024
In the field of DNA applications, plasmid DNA (pDNA) has always been highly favored due to its exceptional stability, ease of production, storage, and transportation. However, as scientific research continues to advance, a series of novel DNA types, ...
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Championing Reporter RNA Modification Methods
Nov 08, 2024
When choosing which method of reporter mRNA modifications is preferable, there is no definitive answer as each method and reporter gene has its own advantages and applicable scenarios. Here are some common mRNA modification methods and reporter genes...
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Overcoming Challenges in Recombinant Protein Purification
Nov 07, 2024
In recent decades, recombinant proteins have proven crucial in combating various diseases, demonstrating great potential. With advancements in genetic engineering, significant breakthroughs have been made in protein drug research. Technologies like f...
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Investigate the Purity of RNA: Ion Exchange Chromatography
Nov 06, 2024
Ion-exchange chromatography effectively purifies RNA by separating molecules with different charges. Depending on their protonation state at various pH levels, RNA molecules can carry positive or negative charges. This property is utilized in ion exc...
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CVB1-VLP: The Pioneer of Enterovirus VLP Vaccines
Nov 05, 2024
Coxsackievirus B1 (CVB1), a member of the enterovirus B species, is a common cause of acute and chronic myocarditis, dilated cardiomyopathy, and purulent meningitis. However, there is currently no vaccine against CVB1. In June 2023, researchers from ...
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