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DNA Vaccine

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DNA Vaccines

DNA Vaccine
DNA vaccine for human use

The low immunogenicity in humans still poses a big challenge to DNA vaccine application despite the progress in animal models. Furthermore, the exploration of DNA vaccines for infectious diseases, such as human immunodeficiency viruses (HIV), tuberculosis, and malaria, has prompted the development of diverse optimization strategies in subsequent years.

ZyCoV-D, developed by Zydus Cadila, was the first approved DNA vaccine against SARS-COV-2.

Uses Brand Name Target/Indication Stage Company
Prophylactic vaccine ZyCoV-D Spike-protein; SARS-CoV-2 Emergency Use Authorization in India Zydus Cadila

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Timeline of DNA Vaccine Development

DNA vaccine for animal use

DNA vaccines in veterinary applications have made great progress as various products have obtained licenses for infectious diseases. To date, DNA vaccines have been successfully approved for preventing H5N1 in chickens (ExactVac), West Nile virus in horses (West Nile-Innovator), infectious haematopoietic necrosis virus in schooled salmons (Apex-IHN), as well as Salmon alphavirus subtype 3 in Atlantic salmon (Clynav).

Uses Brand Name Species Target/Indication Licensed date/ Country Company
Prophylactic vaccine West Nile-Innovator Horses West Nile Virus (WNV) 2005/USA USA CDC, Fort Dodge Animal Health
Apex-IHN Salmon Infectious haematopoietic necrosis virus (IHNV) 2005/Canada Novartis Animal Health, Elanco
Clynav Salmon Salmon alphavirus subtype 3 (SAV3) 2016/EU Elanco
ExactVac Poultry Avian Influenza A (H5N1) 2017/USA AgriLabs, Huvepharma
Yaohai Bio-Pharma Offers One-Stop CDMO Solution for DNA Vaccine
  • Microbial Strain Engineering and Screening
  • Microbial Cell Banking (PCB/MCB/WCB)
  • Upstream Process Development
  • Downstream Process Development
  • Formulation Development
  • GMP Manufacturing
  • Fill and Finish
  • Analytical and Testing
  • Regulatory Affairs
Reference:

[1] Pagliari S, Dema B, Sanchez-Martinez A, Montalvo Zurbia-Flores G, Rollier CS. DNA Vaccines: History, Molecular Mechanisms and Future Perspectives. J Mol Biol. 2023 Dec 1;435(23):168297. doi: 10.1016/j.jmb.2023.168297.

[2] Kutzler, M., Weiner, D. DNA vaccines: ready for prime time?. Nat Rev Genet 9, 776–788 (2008). https://doi.org/10.1038/nrg2432.

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