Antigen
Antigen is a foreign particle or an allergen binding to a specific antibody or T-cell receptor. Due to their ability to stimulate immune response and high affinity with antibodies, antigens from viruses, bacteria, protozoa, and even tumor cells, is widely used as vaccine composition and diagnostic tool.
Commonly used antigens in vaccines or antibody diagnosis kits
| Derivation | Antigens |
| Hepatitis B Virus (HBV) | Hepatitis B surface antigen (HBsAg), Hepatitis B core antigen (HBcAg) |
| Hepatitis C Virus (HCV) | Core protein and nonstructural proteins (NS3, NS4 and NS5) |
| Hepatitis E Virus (HEV) | HEV ORF2 |
| Human Immunodeficiency Virus (HIV) | HIV core and envelope proteins |
| Human T-Lymphotropic Virus (HTLV) | gp21, p24 antigen |
| Cytomegalovirus (CMV) | Pending update |
| Rubella Virus | E1 glycoprotein, E2 glycoprotein |
| Tuberculosis | ESAT6, CFP10 |
| Treponema pallidum | 15 kDa lipoprotein (Tp15), 17 kDa lipoprotein (Tp17), 44.5 kDa lipoprotein (Tp44.5, TmpA), and 47 kDa lipoprotein (Tp47) |
| Trypanosoma cruzi | FP3, FP6, FP10, and TcF antigens |
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- Microbial Strain Engineering and Screening
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- Upstream Process Development
- Downstream Process Development
- Formulation Development
- GMP Manufacturing
- Fill and Finish
- Analytical and Testing
- Regulatory Affairs
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